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This review explores recent advances in understanding molecular mechanisms of tissue regeneration in mammals and suggests potential therapeutic targets, but it reports no new clinical results.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.

This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.

This review examines the evolving field of nanozymes, highlighting their unique properties and biocatalytic capabilities that challenge traditional concepts of biocatalysis, with implications for sustainable applications and potential roles in physiological processes and disease pathogenesis.

This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.

This review examines how mesenchymal stem cells and their derivatives may enhance skin regeneration and rejuvenation, but it reports no new clinical results; the authors suggest iPSC-derived MSCs hold promise for future therapies.

This review discusses recent advances in the therapeutic potential of exosomes for wound healing, highlighting their benefits and challenges but reports no new clinical results.

This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.

This review highlights how advanced nanocarrier and microneedle-based transdermal drug delivery strategies can potentially improve the treatment of skin diseases by enhancing site-specific drug delivery, increasing skin penetration, and reducing systemic toxicity compared to conventional methods.

This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results.

This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.

This study observed that in aged mouse skin, there was an increase in IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells, and blocking IL-17 signaling reduced skin inflammation and delayed age-related changes, suggesting it as a potential target to mitigate skin aging.

In this study, researchers created a core-shell nanozyme, CeO2@ZIF-8/Au, which autonomously regulates ROS levels to efficiently eliminate bacteria, reduce inflammation, and promote wound healing by balancing ROS generation and scavenging in response to environmental conditions.

In this study, researchers developed a method to control the valence states of Mo in nanozymes, optimizing their activity for ROS-related therapies, particularly acute kidney injury treatment, and enabling real-time monitoring with photoacoustic imaging.

This study found that micro-needling with cosmeceuticals or platelet-rich plasma significantly improved wrinkles, skin laxity, scar softening, and hair growth over 12 months, with minimal side effects, and that the best results occur with pigment and platelet massaging between 5 to 30 minutes post-treatment.

This review assesses the current literature on COVID-19's effects on male sexual and reproductive health, highlighting significant research gaps and providing guidance for patient counseling.

This review discusses the role of pharmacological sciences in advancing regenerative medicine technologies but reports no new experimental findings; the authors advocate for increased pharmacologist involvement to drive innovations.

This review examines the evolving understanding of lymphatic vessel development, emphasizing new cellular mechanisms and lineage diversity, while discussing experimental methods and identifying key knowledge gaps.

This article reviews organotypic skin culture systems and their applications in dermatological research, highlighting their ability to model human epidermal conditions in vitro, but it reports no new clinical results.

This article discusses stem cell-based therapies for wound healing and highlights their potential for tissue repair and regeneration, without presenting new clinical results.

This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.

This chapter reviews surface plasmon resonance (SPR) methodology and its applications in basic science and human disease without reporting new clinical results.

This review discusses the development and applications of microneedles, particularly through 3D printing, highlighting their potential in transdermal drug delivery but reporting no new results.

This review discusses the mechanisms and engineering techniques for enhancing the targeted delivery of extracellular vesicles in therapies but reports no new clinical findings; the authors encourage further exploration to advance clinical applications.

This review discusses pyrene excimer nucleic acid probes for detecting biomolecules and protein-DNA interactions and reports no new experimental findings.

This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.

This study found that nanostructured lipid carriers enhanced the skin penetration and retention of minoxidil compared to solid lipid nanoparticles, suggesting they could be a promising method for topical delivery.

This study found that male liver cirrhosis patients have higher estradiol levels and lower dehydroepiandrosterone sulfate, leading to hormonal imbalances favoring estradiol, but without changing sex hormone-binding globulin's binding properties.