ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair
March 2024
in “
Nano-Micro Letters
”
TLDR The nanoplatform helps heal wounds by balancing bacteria-killing and inflammation-reducing functions.
The study presents a core–shell nanozyme, CeO2@ZIF-8/Au, designed to regulate reactive oxygen species (ROS) levels for effective wound repair. This nanoplatform combines ROS generation and scavenging functions, allowing it to kill bacteria, reduce inflammation, and promote healing. The Au nanoparticles on the shell generate ROS to eliminate bacteria, while the CeO2 core, initially encapsulated by ZIF-8, is gradually released in acidic environments to scavenge excess ROS. This dual function ensures a balanced ROS level, highlighting the potential of this technology in developing advanced antibacterial therapies.
