This study found that nanoparticles developed with minoxidil-loaded thiolated β-cyclodextrins showed improved drug retention on hair surfaces and did not cause skin irritation in rabbits, suggesting potential for topical scalp disease treatment.
August 2023 in “Medicina-lithuania” This review discusses the degenerative effects of anabolic-androgenic steroids on the nervous system and reports no new experimental results, aiming to increase public awareness of their health risks.
July 2023 in “Journal of Clinical Medicine” This study reviews current treatments for PCOS and evaluates Tirzepatide as a potential option for its management, suggesting possible benefits for those with obesity and metabolic syndrome but not for those of normal weight.
June 2023 in “QJM: An International Journal of Medicine” This study found that combining fractional CO2 laser treatment with platelet-rich plasma led to a statistically significant improvement in hair regrowth for male androgenetic alopecia, compared to using the laser treatment alone.
June 2023 in “Journal of Biological Chemistry” In this study, the authors identified and characterized the Get3d protein, conserved across plants and photosynthetic bacteria, which localizes to the chloroplast in Arabidopsis thaliana and potentially plays a role in tail-anchored protein targeting, linked to photosynthesis homeostasis.
December 2022 in “Otorhinolaryngology, Head and Neck Pathology.” This study found that applying photobiomodulation therapy after septoplasty helped reduce pain and mitigate changes in the autonomic nervous system compared to those who did not receive the therapy.
February 2022 in “International journal of KIU” This review discusses genetic susceptibility and dietary factors influencing COVID-19 severity and summarizes the genetic variants linked to infection outcomes, but it reports no new clinical results.
December 2021 in “International journal of minor fruits, medicinal and aromatic plants” This review identifies common medicinal plant species in Sri Lankan home gardens and discusses their traditional Ayurvedic uses, but it reports no new clinical results.
September 2020 in “Nature, Environment and Pollution Technology/Nature, environment and pollution technology” This study found that Wistar rats fed with grass extracts from mining areas accumulated trace metals, particularly in the spleen, leading to organ pathology and signs of toxicity.
January 2020 in “International journal of current research and review” This study found that high exposure to plastics was associated with increased chances of irregular menstrual cycles and symptoms similar to polycystic ovary syndrome in adolescent girls.
January 2011 in “Der Pharmacia Lettre” In this study, pig oil was found to significantly promote hair growth in Wister rats, performing better than the standard Minoxidil treatment from the 15th day onward.
This study found no significant difference in hair outcomes between patients using Minoxidil 1 shampoo and a placebo shampoo for alopecia over four months.
717 citations
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June 2010 in “Nature” This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.
306 citations
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April 2019 in “International Journal of Molecular Sciences” This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.
221 citations
,
January 2014 in “Human Reproduction” This study found that the prevalence of polycystic ovary syndrome was 16.6% with Rotterdam criteria but decreased to 6.3% or 8.5% when using alternative criteria involving antral follicle count or anti-Müllerian hormone.
175 citations
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January 2020 in “European Journal of Endocrinology” These guidelines recommend testing thyroid function in patients with obesity due to common hypothyroidism, and highlight that weight loss is crucial for addressing hormonal imbalances, with only modest weight loss benefits from treating endocrine disorders.
175 citations
,
August 1997 in “Nature Genetics”
164 citations
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April 2008 in “Cochrane library” This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.
156 citations
,
August 2016 in “Journal of controlled release” This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.
152 citations
,
October 2010 in “Archives of Dermatology” This study found that daily oral finasteride may increase hair count and improve hair appearance assessments in men with androgenetic alopecia, but it also appears to raise the risk of sexual dysfunction.
115 citations
,
March 2019 in “Nature Communications” This study identified significant genetic associations with frontal fibrosing alopecia at four genomic loci, suggesting it is a genetically predisposed immuno-inflammatory disorder influenced by the HLA-B*07: 02 allele.
53 citations
,
April 2021 in “Cell Host & Microbe” This study found that skin microbiota, particularly in wild-type mice, promotes wound-induced hair follicle neogenesis and wound healing, highlighting the potential downsides of routine antibiotic use on skin regeneration.
52 citations
,
January 2020 in “Scientific Reports” This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.
51 citations
,
August 2015 in “Cochrane library” This systematic review reports that there is currently no evidence supporting methotrexate for maintaining remission in ulcerative colitis; further large-scale trials are needed to assess its efficacy and safety.
48 citations
,
February 2016 in “Scientific Reports” This study reports the creation of rat liver stem cell lines that can differentiate into hepatocytes and suggests they might be useful for pharmacological and regenerative medicine applications.
39 citations
,
March 2022 in “Infection” Many recovered COVID-19 patients in Saudi Arabia still experience symptoms like fatigue and anxiety, especially older adults and those with other health issues.
31 citations
,
September 2013 in “Stem Cells” This study suggests that canonical BMP signaling, particularly involving Smad1 and Smad5, plays a critical role in hair follicle stem cell regulation and hair morphogenesis, with distinct roles from pSmad8.
24 citations
,
August 2022 in “Immunity” This study found that control of Demodex mite colonization in mice required skin ILC2s and IL-13, highlighting their role in maintaining HF integrity and limiting mite overgrowth.
22 citations
,
January 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study developed and validated a mass spectrometric method to measure hydroxy-androgens in serum, which aids in understanding androgen synthesis in castration resistant prostate cancer.
18 citations
,
March 2020 in “Frontiers in Neuroendocrinology” This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.