![The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route](/images/research/73bab8dc-bdf0-45e3-8ef7-73d0d4b93cb1/small/21074.jpg)
research The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route
Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.
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research Autologous Adipose-Derived Stem Cell Versus Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia: Efficacy, Side Effects, and Safety
Both fat-derived stem cells and platelet-rich plasma are effective and safe for hair loss, but stem cells give better results with more side effects.
research The SYP123-VAMP727 SNARE Complex Is Involved in the Delivery of Inner Cell Wall Components to the Root Hair Shank in Arabidopsis
The SYP123-VAMP727 complex is important for transporting materials that harden the root hair shank in Arabidopsis.
research Five Years After Keogh's Review of Regulation in the Aesthetics Sector, What Has Changed?
Some improvements in the aesthetics sector have been made, but patient protection is still lacking due to no compulsory register for practitioners and non-prescription dermal fillers.
research Two Birds That Exclude Each Other: The Renbök Phenomenon
Oral tofacitinib can treat both psoriasis and alopecia universalis by normalizing inflammatory pathways.
research Polycystic Ovarian Syndrome: Comprehensive Diagnosis and Treatment Approaches
The document concludes that managing PCOS requires a comprehensive approach, including lifestyle changes and medication, to improve symptoms and reduce health risks.
research Extended Hair Transplant: Combination of Two Techniques
Combining FUT and FUE hair transplant methods in one session provides more grafts and higher patient satisfaction.
research Beneficial Effects of Finasteride on Hepatic and Pulmonary Immune Response After Trauma Hemorrhage in Mice
Finasteride improves immune response and reduces organ damage after trauma hemorrhage in mice.
research Modeling Share Dynamics by Extracting Competition Structure
The model can predict website market shares by identifying competition among them.
research Creatine Phosphokinase Levels and Isotretinoin Therapy
Isotretinoin can raise CPK levels, so patients need monitoring, especially before surgery.
research Novel Penile Ultrasound Technique to Explain Mechanism of Erectile Dysfunction in Young Patients Using Finasteride for Androgenic Alopecia
Ultrasound shows 96% of young men with erectile dysfunction after using finasteride have abnormal penile tissue.
research Promoting Longevity: A Global Approach
The document concludes that managing health issues like menopause, cardiovascular risk, and hair loss is crucial for promoting longevity in aging women.
research Urticariform Plaques: Delayed Hypersensitivity Reaction Type IV to Enoxaparin
A woman had a delayed allergic reaction to the blood thinner enoxaparin, treated with a steroid cream.
research A Case of Widespread Actinic Granuloma with Associated Drug-Induced Lupus Erythematosus
A man developed a rare skin condition and drug-induced lupus, highlighting the need for biopsy in diagnosing skin issues caused by sunlight.
research Limited Effectiveness of Platelet-Rich Plasma Treatment on Chronic Severe Alopecia Areata
Platelet-rich plasma treatment is not very effective for chronic severe alopecia areata.
research Targeted Immunotherapy for Hair Regrowth and Regeneration
Targeted immunotherapy could be a promising new treatment for hair regrowth.
research An Extract of Leontopodium Alpinum Prolongs Anagen Phase in Human Hair Follicles Ex Vivo
Leontopodium alpinum extract may help reduce hair shedding by keeping hair in the growth phase longer.
research Updates in the Pathogenesis of Alopecia Areata
Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.
research FUE: Basic and Advanced Techniques
FUE hair transplants have improved to give more natural results with less scarring and pain.
research Dermatological Adverse Effects of Chemotherapeutic Agents: Experience from a Tertiary Centre
About 22% of cancer patients had skin-related side effects from chemotherapy, but these were usually not severe enough to halt treatment.
research Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism
The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.
research Comparison of Androgenic Hormone Levels in Various Phenotypes of Polycystic Ovarian Syndrome in High School Girls Aged 14 to 18 Years
Girls with PCOS and menstrual disorders have notably higher androgen hormone levels.
research Cognitive Performance in Adolescents with Anorexia Nervosa: Subgroups in Relation to Neuropsychological Impairment
Some teenagers with anorexia nervosa have worse cognitive abilities, especially in visual and spatial tasks, and this is more common in those with a lower body weight.
research Multiple Flat Warts Due to Tetracycline
Stopping tetracycline can lead to the disappearance of flat warts.
research Post-COVID Telogen Effluvium: The Diagnostic Value of Serum Ferritin Biomarker and the Preventive Value of Dietary Supplements. A Case-Control Study
Dietary supplements might help prevent post-COVID hair loss, but serum ferritin is not a reliable indicator.
research Effect of Topical Gel Administration of Secretome Hypoxia Mesenchymal Stem Cells on IL-10 and TNF-α Gene Expression: An In Vivo Experimental Study in Male Wistar Rats with Fluconazole-Induced Alopecia
SH-MSCs gel can effectively treat alopecia by increasing IL-10 and decreasing TNF-α gene expression.
research Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample
PPAR-γ may be a key target for treating alopecia areata and other skin conditions.
research Scarring Hair Follicle Destruction Is Driven by the Collapse of EGFR-Protected JAK-STAT1-Sensitive Stem Cell Immune Privilege
A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.
research Practical Approach for Treatment Lines of Alopecia Areata: Review Article
The conclusion is that emotional support and a variety of treatments are important for alopecia areata, but more research is needed.
research T Cell and Bacterial Microbiota Interaction at Intestinal and Skin Epithelial Interfaces
T cells and bacteria in the gut and skin help maintain health and protect against disease.