Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, 70% of female androgenetic alopecia patients who did not respond to standard minoxidil experienced clinical improvement after switching to a propylene glycol-free, witch hazel-based 5% minoxidil sulfate solution, with the treatment also being well-tolerated.

This study found that inhibiting the enzyme ornithine decarboxylase (ODC) prevented UVB-induced basal cell carcinomas in a mouse model, suggesting ODC is a potential target for chemoprevention strategies.

In this study, ethanol was found to enhance GABAergic neurosteroid production and inhibit long-term potentiation in rat hippocampal slices via unblocked NMDA receptor activation, effects reversible by specific inhibitors.

This study suggests that specific structural features of minoxidil analogs, such as hydrophobic and hydrogen bond field contributions, are key to enhancing lysyl hydroxylase inhibitory activity, which could inform future hair growth treatments.

In this study, transcriptome analysis identified 68 differentially expressed miRNAs in human dermal papilla cells treated with hydrogen peroxide, suggesting they play a significant role in growth arrest and apoptosis.

This study observed mycobacterial infection with M. xenopi in a pet ferret, noting its resistance to doxycycline, and highlighted the potential zoonotic transmission risk associated with such infections.

In this study, researchers identified and examined males with 17 beta-HSD3 deficiency in a highly inbred Arab population, noting genetic findings and the progression of male characteristics despite being raised as females initially.

This study found that homocysteine-keratin accumulation in human hair increases towards the tips, linked to copper/iron-catalyzed demethylation of methionine, and may contribute to keratin damage.

This study found that sulfation of minoxidil occurs in hair follicles and proliferative keratinocytes, which may be linked to its hair growth stimulation effects.

In this case report, a 3-year-old beagle with recurrent skin lesions and alopecia due to a methicillin-resistant Staphylococcus aureus infection showed significant improvement within 10 days and complete resolution after a 28-day treatment with oral linezolid, alongside fungal infection management.

In this case study, a comprehensive reconstruction approach using autologous fat grafting, follicular unit excision hair transplantation, and scalp micropigmentation led to significant aesthetic and psychosocial improvements in a male patient with severe facial and scalp burn injuries.

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

This study highlights the potential of ZDHHC17 methylation as a biomarker or therapeutic target in addressing skin aging, offering new insights into its molecular mechanisms.

This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.

In this study, researchers developed a novel periodate oxidation method for extracting keratin micro-units from waste hair and feathers, achieving yields of 31.28% and 20.64% respectively, enhancing the stability of oil-in-water emulsions and suggesting potential for sustainable biomaterial production.

This study developed and validated a Gas Chromatography-Flame Ionization Detection method for assessing minoxidil, which shows good precision, accuracy, and specificity for quality control and pharmacokinetic studies.

This study observed that methylene blue, a mitochondrial-targeted antioxidant, promotes hair follicle stem cell proliferation and viability through reduced oxidative stress and enhanced β-catenin signaling, and it may also protect against hair loss related to glucagon-like peptide-1 receptor agonists by reducing metabolic stress.

This study suggests that most pediatric minoxidil exposures reported to Texas poison centers were unintentional, typically non-serious, and often manageable at home, despite concerns about serious adverse effects.

This study suggests that rat skin may synthesize minoxidil sulphate independently, implying the skin could contribute to minoxidil's hair growth promotion without help from the liver or other organs.

This study investigated how the antioxidant MitoQ and the enzyme CYP19A1 influence mitochondrial function in androgenetic alopecia. In a mouse model, both CYP19A1 overexpression and MitoQ treatment improved mitochondrial health and reversed DHT-induced hair loss factors, suggesting potential therapeutic targets for this condition.

This study suggests that chronic treatment with TPA in mouse skin selectively expands a keratinocyte subpopulation hyperinducible for ODC, which may be a key target for neoplastic transformation.

This study demonstrated that a metric based on rotational echo intensity in 2H magic-angle spinning NMR can derive kinetic information for conformational exchange without complex modelling, achieving activation barriers consistent with prior findings.

This study suggests that melatonin may enhance wool growth in cashmere goats by activating sulfur metabolism genes and high-sulfur protein genes, which are crucial for providing sulfur-containing amino acids needed for wool quality.

This study found that the nonionic surfactant Brij 78 stabilized cationic minoxidil microparticles against aggregation, maintaining their substantivity in the presence of excess anionic surfactant.

This study in the Arab population of Gaza described pseudohermaphroditism due to 17β-HSD deficiency, where individuals showed marked masculinization after puberty despite inadequate androgen proportions.

This study found that Mentha pulegium essential oil had a stronger protoscolicidal effect against Echinococcus granulosus in vitro than Mentha piperita, showing dose- and time-dependent effects.

This study found that methyl nonanoate and methyl caprate significantly enhanced the skin penetration of minoxidil compared to solutions with other common enhancers like Azone, DMSO, or DEET.

This narrative review discusses various microbes associated with fermentation and diseases in plants, animals, and humans, reporting no new research results.

This study found that dietary supplementation with 0.2% MSM improved hair quality in kittens and had no significant negative effects on their growth performance, antioxidant capacity, or gut microbiota.

This study found that elevated epidermal ODC activity in transgenic mice promotes skin tumor development by recruiting bulge stem cells, rather than through reactive oxygen species generation by polyamine catabolic oxidases.