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Certain gene variations might help protect against insulin resistance and glucose intolerance in people with Polycystic Ovary Syndrome.

Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

High lactate dehydrogenase activity is not necessary for the growth of squamous cell carcinoma.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

Sheep wool follicles can metabolize both glucose and acetate using different pathways important for wool growth.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Adding soybean oil to Nonomuraea dietziae increases production of a beneficial compound by improving metabolism and enzyme systems.

Certain metabolites are lower in women with PCOS and could be potential markers for the condition.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Skin and nail problems like hair loss, dry skin, and fungal infections are common in people with long-term Type 2 Diabetes and can be prevented with good blood sugar control and foot care.

Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.

Antioxidants can benefit skin health but should be used carefully to avoid negative effects.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.

Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

The circadian clock in skin cells controls their growth and rest cycles.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.

SHBG may be a useful early indicator and treatment target for PCOS.

Mutations in the LSS gene cause a rare type of hereditary hair loss.

Premature graying of hair may suggest health issues and currently lacks effective treatments.