Cutaneous Manifestations of Diabetic Peripheral Neuropathy

    January 2017 in “ Dermato-endocrinology ”
    Sowmya Naga Dogiparthi, K. Muralidhar, Krishna G Seshadri, R Sudha
    TLDR Skin and nail problems like hair loss, dry skin, and fungal infections are common in people with long-term Type 2 Diabetes and can be prevented with good blood sugar control and foot care.
    The study documented early cutaneous changes in 205 patients with Type 2 Diabetes Mellitus (DM) to raise awareness about the importance of controlling diabetes to prevent complications of Diabetic Peripheral Neuropathy (DPN). Common skin changes included peripheral hair loss (90.2%), xerosis (82%), and anhydrosis (79%). Nail changes like onychomycosis (80.5%) and onychauxis (25.8%) were also prevalent. The study found significant correlations between glycemic levels and conditions such as xerosis, varicose veins, anhydrotic skin, and plantar fissures. The results emphasized the need for glycemic control and foot care to prevent severe complications like ulcers and amputations. The document discussed the pathogenesis and clinical aspects of DPN, emphasizing the role of hyperglycemia in initiating metabolic nerve injury through pathways like Protein Kinase C and the polyol pathway. It highlighted the prevalence of DPN in diabetic patients, particularly those aged 51-60, and the associated cutaneous manifestations such as peripheral hair loss, xerosis, and plantar fissures. The study underscored the importance of glycemic control, proper footwear, and regular medical care to prevent complications. It also noted that despite normal BMI, Asian Indians are genetically predisposed to Type 2 Diabetes Mellitus, leading to a higher incidence of DPN.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 34 results

    Similar Research

    5 / 1000+ results
      Wound Healing and Hair

      research Wound Healing and Hair

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Certain drugs can cause lupus, stopping these drugs is the main treatment. NB-UVB phototherapy clears psoriasis faster when applied three times a week. Monoclonal antibodies and oral pimecrolimus are effective in treating psoriasis. Smoking and drinking are linked to psoriasis in men. No direct link between low iron and hair loss was found. Vaccines are effective against genital herpes and human papillomavirus type 16.
      Medical Practice: Therapy and Adverse Reactions

      research Medical Practice: Therapy and Adverse Reactions

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Blood pressure drugs can cause skin lupus, but it improves after stopping the drug. The glycoprotein D vaccine works against genital herpes in some women, and the HPV-16 vaccine reduces HPV-16 infection and related diseases. More frequent light therapy clears psoriasis faster. A cream called imiquimod effectively treats a type of skin cancer. Iron supplements don't necessarily help with chronic hair loss in women.
      Internal Medicine: Retrospective Review of 120 Patients Over a 10-Year Period

      research Internal Medicine: Retrospective Review of 120 Patients Over a 10-Year Period

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Certain drugs can cause skin lupus, but stopping the drug usually helps. Vaccines work against smallpox, genital herpes, and a type of human papillomavirus. More frequent light therapy clears psoriasis faster. Certain treatments work for psoriasis and dermatitis. A specific cream effectively treats a type of skin cancer. Low iron levels aren't directly linked to chronic hair loss.
      Phototherapy, Photomedicine, and Pigmentary Disorders

      research Phototherapy, Photomedicine, and Pigmentary Disorders

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Stopping certain drugs can improve skin conditions, arsenicosis affects over half of a Bangladeshi village, males are more vulnerable, and certain treatments are effective for warts, acne, and psoriasis. Smoking and drinking are linked to psoriasis in men, a cream helps with a type of skin cancer, and low iron levels don't directly cause chronic hair loss in women.
      Surgery And Laser

      research Surgery And Laser

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Various skin conditions like cutaneous lupus erythematosus, psoriasis, and basal cell carcinoma can be effectively treated with antihypertensive agents, NB-UVB phototherapy, and imiquimod cream respectively. Vaccines are effective against genital herpes and HPV-16 infection. Early intervention is crucial for conditions like diabetic foot ulcers and neonatal herpes. Certain dyes can cause hand dermatitis, and there's a link between smoking/drinking and psoriasis in men. No direct link was found between low iron levels and chronic hair loss in women.