Integrating Multi-Omics Analyses of Nonomuraea Dietziae to Reveal the Role of Soybean Oil in [(4′-OH)MeLeu]4-CsA Overproduction

    July 2017 in “ Microbial Cell Factories ”
    Huanhuan Liu, Di Huang, Lan Jin … Jianping Wen
    Studysummary This study found that supplementing soybean oil significantly increased the production of the cyclosporine A derivative [(4'-OH)MeLeu]4-CsA by 55.6%, offering potential enhancements for its clinical application.
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    Research cited in this study 3

    1. Identification of a Cyclosporine-Specific P450 Hydroxylase Gene Through Targeted Cytochrome P450 Complement Disruption in Sebekia Benihana Applied and Environmental Microbiology · 2013
    2. Induction of Synapse Associated Protein 102 Expression in Cyclosporin A-Stimulated Hair Growth Experimental Dermatology · 2008
    3. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001