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    Glossary Mesenchyme

    loosely organized embryonic connective tissue with differentiation potential

    Mesenchyme is a type of loosely organized, embryonic connective tissue that is primarily made up of mesenchymal cells. These cells have the ability to differentiate into various cell types, including those that form bones, muscles, and the circulatory system. In the context of hair and alopecia, mesenchymal cells play a crucial role in the development and regeneration of hair follicles.

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    1. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005 · 417 citations
    2. Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling Seminars in Cell & Developmental Biology · 2012 · 300 citations
    3. Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging International Journal of Molecular Sciences · 2017 · 132 citations
    4. The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization Experimental Dermatology · 2009 · 131 citations
    5. Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis Genes & development · 2010 · 95 citations
    6. Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering Journal of Dermatological Science · 2013 · 57 citations
    7. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations 2003 · 54 citations
    8. Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells Scientific Reports · 2017 · 42 citations
    9. Odontogenic Potential of Mesenchymal Cells from Hair Follicle Dermal Papilla Stem Cells and Development · 2008 · 42 citations
    10. Androgen receptors are only present in mesenchyme-derived dermal papilla cells of red deer (Cervus elaphus) neck follicles when raised androgens induce a mane in the breeding season 2001 · 24 citations
    11. Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile 2016 · 18 citations
    12. The concept of the onychodermis (specialized nail mesenchyme): an embryological assessment and a comparative analysis with the hair follicle Journal of Cutaneous Pathology · 2013 · 17 citations
    13. Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles International journal of molecular sciences · 2021 · 14 citations
    14. β-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal Progenitors Frontiers in Cell and Developmental Biology · 2022 · 12 citations
    15. Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators PLOS Computational Biology · 2014 · 12 citations
    16. Expression of extracellular matrix in hair follicle mesenchyme in alopecia areata British Journal of Dermatology · 1990 · 11 citations
    17. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance 2019 · 11 citations
    18. Generation of bioengineered feather buds on a reconstructed chick skin from dissociated epithelial and mesenchymal cells Development Growth & Differentiation · 2016 · 10 citations
    19. Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome Journal of Clinical Investigation · 2022 · 9 citations
    20. Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation Biomedicines · 2022 · 7 citations
    21. Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow Cell regeneration · 2020 · 6 citations
    22. Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species European journal of histochemistry · 2009 · 6 citations
    23. Mesenchymal stem cell‐derived exosomes for organ development and cell‐free therapy Nano select · 2021 · 4 citations
    24. Estrogen modulates mesenchymal-epidermal interactions in the adult nipple Development · 2017 · 4 citations
    25. Ptch2 is a Potential Regulator of Mesenchymal Stem Cells Frontiers in Physiology · 2022 · 3 citations
    26. Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration Journal of Clinical Medicine · 2021 · 3 citations
    27. Development and Molecular Characterization of Human Placental Mesenchymal Stem Cells from Human Aborted Fetal Tissue as a Model to Study Mechanism of Spontaneous Abortion Advances in Stem Cells · 2014 · 3 citations
    28. Mesenchyme governs hair follicle induction bioRxiv (Cold Spring Harbor Laboratory) · 2023
    29. Preclinical efficacy and safety evaluation of a topical mesenchymal stem cell derived conditioned media gel for oral mucositis management Scientific Reports · 2026
    30. Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system Biochemical and Biophysical Research Communications · 2026