Skin Fibroblast Heterogeneity and Plasticity Are Determined by the Local Niche
September 2019
in “
Journal of Investigative Dermatology
”
dermal fibroblasts Wnt/β-catenin Hedgehog pathway TGFβ pathway ECM components neoplastic epidermal cells hair cycle dermal mesenchyme fluorescence-activated cell sorting FACS FAP+/CD90- cells FAP-/CD90+ cells FAP+/CD90+ cells ACTA2 MGP PPARγ CD36 adipogenic differentiation Wnt signaling TGF-beta pathway extracellular matrix FAP positive cells CD90 positive cells adipocyte differentiation
Studysummary This study suggests that human skin contains distinct fibroblast subsets with unique expression profiles and functions, which can be isolated to investigate their role in skin pathogenesis.
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