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This preliminary study observed that melanoblasts are preserved in the white hair follicles of segmental vitiligo lesions.

This study observed that the topical skin-whitening agent rhododendrol induced skin depigmentation in approximately 16,000 consumers, linked to melanocyte cytotoxicity and immune reactions.

This study reports that hair follicle neural crest stem cells in mice can be differentiated into melanocytes, potentially aiding repigmentation in vitiligo-affected areas.

In this study, silencing P-cadherin in human scalp hair follicles reduced melanogenesis and associated protein expression, suggesting P-cadherin is crucial for normal hair pigmentation via GSK3β-mediated Wnt signaling.

This study found that dual inhibition of BACE1 and BACE2 in mice affects melanosome maturation and causes dose-dependent hair depigmentation without altering retinal morphology.

GNPTAB gene is crucial for normal hair color in humans and mice.

New treatments and drugs show promise for improving skin pigmentation and regeneration.

This study suggests that increased Wnt signaling may promote excessive differentiation of melanocytes, leading to exhaustion of melanocyte stem cells and hair graying in aged mice.

This study found that Polygonum multiflorum radix ethanol extract may promote melanin synthesis, potentially helping to turn gray hair back to black by enhancing antioxidant activity and increasing tyrosinase expression.

This study found that in Rex rabbits, exosomal miR-222-3p from dermal papilla cells suppresses melanogenesis in melanocytes by targeting the SOX10 gene, highlighting a novel mechanism by which exosomes influence melanin production.

This article discusses a new global consensus on the classification of vitiligo, describing histopathological findings and outlining treatment strategies, but reports no new clinical results.

This review discusses the diverse roles and potential skin health benefits of melatonin, highlighting its anti-inflammatory, antioxidant, and protective effects but reports no new clinical results.

In this study, topical inhibition of casein kinase 1 in mice was found to enhance melanocyte precursor migration and eumelanin production, suggesting potential applications for treating vitiligo and graying hair through KitL/c-Kit signaling pathway activation.

This research describes methods to activate melanocyte stem cells during hair follicle regeneration and to isolate melanocytes from neonatal mouse skin, with the aim of studying melanogenesis for potential clinical applications.

This review explores the mechanisms of skin repigmentation and therapeutic strategies for pigmentation disorders following burn injuries, but it presents no new clinical results.

This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.

This study found that Wnt signaling in the hair follicle is crucial for coordinating the behavior of epithelial and melanocyte stem cells, which drives hair regeneration and melanocyte differentiation in mice.

This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.

This study observed that PCE-DP may improve skin pigmentation by increasing epidermal turnover and inhibiting melanin uptake and inflammation in human epidermal keratinocytes.

This case study describes an elderly woman with distinctive black hair patches and scalp pigmentation, but it does not provide a diagnosis or new findings.

This study found that DNA hypermethylation was present in melasma lesions, and treatments with sunscreen, niacinamide, and retinoic acid were associated with decreased methylation and clinical improvement.

This study revealed that different coat patterns in cats and cheetahs are related to variations in the aminopeptidase Q gene and endothelin-3 expression, which affects pigment production.

This laboratory study found that collagen matrices with high-sulfated hyaluronan may enhance the cultivation of human keratinocytes and melanocytes from hair follicles for epidermal graft development.

This study observed that amelanotic melanocytes from human hair follicles appeared morphologically immature, suggesting they might not transfer melanosomes into keratinocytes.

This article discusses strategies for changing hair color by regulating target genes in hair follicles using advanced delivery systems, but it reports no new experimental findings.

This study found that treating human skin explants with TPA increased the number of certain melanocyte phenotypes in the interfollicular epidermis, suggesting that this ex vivo model can effectively replicate human skin's pharmacologic responses for studying potential treatments.

This study found that finasteride decreases melanin levels in melanocyte and melanoma cells by inhibiting MC1R, without causing cytotoxicity, suggesting its potential role in regulating melanogenesis.

This study describes vitiligo as a chronic disorder where genetic, environmental, and immune factors contribute to skin depigmentation, with associations to other autoimmune diseases and potential links to oxidative stress.

This study found that mouse skin can produce and metabolize serotonin and N-acetylserotonin, with activity influenced by location, physiological skin status, cell type, and mouse strain.

This review discusses the protective and stress-buffering roles of melatonin in skin functions and structures but does not present new clinical findings.