Sulfated Hyaluronan-Containing Artificial Extracellular Matrices Promote Proliferation of Keratinocytes and Melanotic Phenotype of Melanocytes from the Outer Root Sheath of Hair Follicles

    March 2019 in “ Journal of Biomedical Materials Research Part A ”
    M. Schneider, Sandra Rother, Stephanie Möller, Matthias Schnabelrauch, Dieter Scharnweber, Jan‐Christoph Simon, Vera Hintze, Vuk Savković
    TLDR Sulfated hyaluronan in collagen helps hair follicle cells grow and develop better for skin grafts.
    The study aimed to improve cultivation conditions for human keratinocytes (HUKORS) and melanocytes (HUMORS) from the outer root sheath of hair follicles to generate epidermal grafts. Researchers used artificial extracellular matrix coatings made of collagen and hyaluronan with varying sulfation degrees. They found that these matrices supported the proliferation of HUKORS and enhanced the balance between proliferation and melanotic phenotype in HUMORS. High-sulfated hyaluronan in collagen matrices increased the expression of melanotic genes in HUMORS, potentially by interacting with the CD44 receptor or concentrating signaling mediators. These findings suggested that collagen matrices with sulfated hyaluronan could significantly improve the development of ORS-based epidermal grafts.
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