Sulfated Hyaluronan-Containing Artificial Extracellular Matrices Promote Proliferation of Keratinocytes and Melanotic Phenotype of Melanocytes from the Outer Root Sheath of Hair Follicles

March 2019 in “ Journal of Biomedical Materials Research Part A ”

M. Schneider, Sandra Rother, Stephanie Möller, Matthias Schnabelrauch, Dieter Scharnweber, Jan‐Christoph Simon, Vera Hintze, Vuk Savković

sulfated hyaluronan artificial extracellular matrix keratinocytes melanocytes outer root sheath hair follicles collagen CD44 receptor epidermal grafts

Studysummary This laboratory study found that collagen matrices with high-sulfated hyaluronan may enhance the cultivation of human keratinocytes and melanocytes from hair follicles for epidermal graft development.

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research A Human Serum-Enriched Medium Formulation Supports High Viability and Marker Expression in Primary Melanocyte Cultures from the Outer Root Sheath and Epidermis

2 citations , August 2017 in “Experimental Dermatology”

This study developed a new melanocyte cultivation medium without chemical mitogens, melanogenesis enhancers, or bovine products, demonstrating successful proliferation and melanotic differentiation of human melanocytes from hair follicles.

research Melanocytes from the Outer Root Sheath of Human Hair and Epidermal Melanocytes Display Improved Melanotic Features in the Niche Provided by cGEL, Oligomer-Cross-Linked Gelatin-Based Hydrogel

7 citations , July 2016 in “Journal of Biomedical Materials Research Part A”

This study found that a novel hydrogel scaffold, cGEL, significantly increased melanin production and melanotic gene expression in human melanocytes compared to other graft materials, suggesting its potential as a superior carrier for skin grafting.

research Melanocytes from the Outer Root Sheath of Hair Follicles Cultivated on Collagen Membrane Improve Their Melanotic Properties

5 citations , January 2012 in “Journal of Tissue Science & Engineering”

In this study, collagen I decellularized scaffolds enhanced the growth and melanotic properties of hair follicle melanocytes, suggesting their potential as effective carriers for transplantation in vitiligo treatment.