Melanocytes from the Outer Root Sheath of Human Hair and Epidermal Melanocytes Display Improved Melanotic Features in the Niche Provided by cGEL, Oligomer-Cross-Linked Gelatin-Based Hydrogel

July 2016 in “ Journal of Biomedical Materials Research Part A ”

Katharina Sülflow, M. Schneider, Tina Loth, Christian Kascholke, Michaela Schulz‐Siegmund, Michael C. Hacker, Jan‐Christoph Simon, Vuk Savković

melanocytes outer root sheath epidermal melanocytes cGEL gelatin-based hydrogel melanin PAX3 PMEL TYR MITF Collagen Cell Carrier polycaprolactone skin transplantation gelatin collagen PCL

TLDR cGEL hydrogel improves melanin production in skin cells, making it a promising option for skin treatments.

The study investigated the use of a hydrogel called cGEL as a potential carrier for human melanocytes derived from the outer root sheath of hair follicles (HUMORS) and normal human epidermal melanocytes (NHEM) for non-invasive treatments of depigmented skin disorders. The cGEL, made from enzymatically degraded bovine gelatin and chemically cross-linked with specific oligomers, provided a supportive 3D environment that enhanced melanin production and the expression of melanotic genes (PAX3, PMEL, TYR, and MITF) compared to other materials like Collagen Cell Carrier® and polycaprolactone matrices. This suggests that cGEL could be a superior candidate for grafting carriers in skin transplantation procedures.

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Melanocytes from the Outer Root Sheath of Human Hair and Epidermal Melanocytes Display Improved Melanotic Features in the Niche Provided by cGEL, Oligomer-Cross-Linked Gelatin-Based Hydrogel

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