7 citations
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July 2016 in “Journal of Biomedical Materials Research Part A” cGEL hydrogel improves melanin production in skin cells, making it a promising option for skin treatments.
January 2026 in “Current Issues in Molecular Biology” This study investigated the molecular mechanisms of pigmentation in alpaca melanocytes over-expressing miR-5110. Using high-throughput RNA sequencing, researchers identified 91,976 unigenes, with 13,262 exceeding 2000 nucleotides. Key pathways related to melanogenesis, including MAPK, Wnt, and cAMP signaling, were identified. Compared to controls, 162 genes were upregulated and 41 downregulated in miR-5110 over-expressed melanocytes. Differential expressions of genes such as DKK3, Pmel, IGF1R, CDK5, Ednrb, Kitl, Myc, and S100 were confirmed via qRT-PCR. Notably, Kitl and MAPKAPK3 emerged as candidate genes for miR-5110-regulated melanogenesis, offering new insights into pigmentation processes.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” The model can effectively test gene functions and drug responses in human skin.
2 citations
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September 2020 in “Schweizer Archiv für Tierheilkunde” Swiss Holstein cattle with curly, short hair carry genes from the Simmental breed.
58 citations
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February 2016 in “Scientific reports” Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.