November 2021 in “Journal of Aesthetic Nursing” This study found that injectable platelet-rich fibrin (iPRF) combined with microneedling is a safe and effective treatment for male androgenetic alopecia, but it currently lacks comparison data against other popular therapies.
January 2025 in “Regenerative Biomaterials” This study found that a microneedle patch with recombinant collagen XVII significantly improved hair coverage, follicle density, and angiogenesis in an androgenic alopecia mouse model, showing potential as a novel therapeutic strategy alongside established treatments like minoxidil.
June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study investigated the effects of a recombinant human collagen complex on hair growth, finding it enhanced survival and function of hair follicle stem cells and promoted hair growth in rat models, suggesting its potential for hair loss prevention and hair health maintenance.
1 citations
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June 2025 in “Journal of Cellular and Molecular Medicine” This study explored the role of plant-derived monomers in reversing grey hair, finding that compounds like fraxinol and morin may stimulate melanin production and tyrosinase activity, suggesting potential therapeutic benefits, although further evaluation of their safety and efficacy is needed.
3 citations
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September 2022 in “Animal biotechnology” This study found that knocking down lncRNA MTC in Liaoning Cashmere goat skin fibroblasts inhibited cell proliferation and increased apoptosis, suggesting its role in facilitating cell growth by regulating specific proteins.
This study developed a novel, 3D-printed dissolving microneedle system for delivering minoxidil to treat hair loss, which showed pH-triggered drug release and enhanced hair regrowth in an alopecia mouse model, offering a potentially sustainable and safe transdermal therapy option.
January 2017 in “Seoul National University Open Repository (Seoul National University)” This study found that the N-terminal fragment of AIMP1 enhances hair growth and proliferation of hair follicle stem cells in mice, suggesting its potential as a therapeutic peptide for hair loss treatment.
January 2026 in “Materialia” In this study, porcine collagen acellular dermal matrix scaffolds combined with mice platelet-rich plasma were associated with increased hair density and follicle regeneration in mice with alopecia, suggesting a potential therapeutic approach.
1 citations
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June 2023 in “Chemical engineering journal” In this laboratory study, a novel minoxidil-loaded microneedle patch demonstrated potential for treating alopecia areata by promoting slow drug release and reducing application frequency, while exhibiting antibacterial properties to prevent infection during use.
46 citations
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March 2019 in “Journal of Pineal Research” The study found that melatonin treatment in early postnatal cashmere goats increased both the quantity and quality of cashmere by promoting secondary hair follicle development and enhancing antioxidant enzyme activities.
30 citations
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June 2017 in “Talanta” This review discusses the critical parameters for MALDI IMS sample preparation in skin analysis and highlights its applications in wound healing, neoplasia, and infection research, but reports no new clinical results.
1 citations
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May 2013 in “PubMed” This study found that glycylglycine treatment improved hair softness by enhancing hair alignment and altering internal fiber properties among Japanese women with typically coarse hair.
July 2026 in “Journal of Cosmetic Dermatology” This network meta-analysis found that for female pattern hair loss, microneedling combined with minoxidil ranked highest for hair density and patient satisfaction, while poly-L-lactic acid threads plus minoxidil led in hair diameter; however, the evidence is uncertain and lacks placebo-controlled trials.
7 citations
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August 1985 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that subcutaneous injection of medroxyprogesterone acetate was more effective than intramuscular or topical treatments in reducing hair diameter for hirsute females.
14 citations
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December 1991 in “Annals of the New York Academy of Sciences” This study reports that lower levels of N-myc mRNA are observed when hair growth ceases in certain phases in mice, and attempts to create transgenic mice for further investigation resulted in high embryonic mortality.
17 citations
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May 2021 in “Journal of Cell Science” In this study, the researchers discovered that specific polyamine depletion enhances stemness in hair follicle stem cells through a mechanism independent of mRNA translation.
9 citations
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April 2006 in “International Journal of Dermatology” This article reviews the potential for α-difluoromethylornithine to help control hair growth and prevent cancer, but it does not present new clinical results.
18 citations
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January 2013 in “Evidence-based Complementary and Alternative Medicine” In this study, ALR was found to enhance both the proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells, potentially through specific signaling pathways.
November 2022 in “Journal of Investigative Dermatology” This study found that sodium butyrate, a metabolite from the HF microbiome, significantly delayed catagen onset and promoted key physiological processes in cultured human hair follicles.
September 2017 in “PubMed” In this case report, a Danish family with monilethrix showed varying symptoms, diagnosed via dermatoscopy, microscopy, and gene sequencing. The study highlights that while no cure exists, oral minoxidil shows promise in a single case, and reducing hair trauma remains key for management.
July 2026 in “Journal of Investigative Dermatology” This study in mice found that using modified illite as a carrier for topical minoxidil enabled effective delivery without the solvent toxicity typically associated with minoxidil, while the illite also promoted hair growth through anti-inflammatory and pro-proliferative mechanisms.
September 2024 in “Journal of the American Academy of Dermatology” In this pilot study, minoxidil-treated scalp skin grafts from hair loss patients on mice showed increased expression of key anti-aging biomarkers and hair regrowth, suggesting minoxidil as a potential anti-aging agent by boosting VEGF-A production in hair follicles.
October 2019 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers developed a new solution called CapilGen, showing it increased hair quantity by 35% and density by 25% in clinical trials without side effects, providing a potentially safe and effective treatment for baldness.
2 citations
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October 2025 in “Cells” This review discusses the multifunctional role of PKM2 in promoting cardiac repair and regeneration, highlighting its potential as a therapeutic target in cardiovascular medicine, but reports no new experimental results.
14 citations
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January 2017 in “Annals of Dermatology” In this retrospective study, low-dose methotrexate was observed to be effective and well-tolerated in treating recalcitrant alopecia areata multiplex, achieving complete or near-complete hair regrowth in about 90% of patients despite some experiencing elevated liver enzymes and gastrointestinal discomfort.
December 2022 in “Scientific Reports” This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.
10 citations
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February 2017 in “European journal of neuroscience/EJN. European journal of neuroscience” This study found that local synthesis of 17β-estradiol and 5α-dihydrotestosterone, combined with specific stimulation patterns, is crucial in determining the direction and strength of long-term synaptic effects in the hippocampal CA1 region of male rat slices.
28 citations
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November 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the selective PPARγ modulator GMG-43AC may inhibit unwanted hair growth by inducing catagen phase while preserving hair follicle epithelial progenitor cells, suggesting potential in anti-hirsutism therapy.
December 2025 in “Universal library of medical and health sciences.” This study analyzes contemporary theories and practices to understand key factors influencing the development of the examined phenomenon, proposing trends and practical applications for researchers and practitioners, while acknowledging study limitations and suggesting future research directions.
1 citations
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May 2022 in “Research Square (Research Square)” The study demonstrates that acetate treatment may alleviate PCOS-associated depression in rats by reducing neuroinflammation and modifying epigenetic changes in the brain.