Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 Induces Proliferation of CD34+ Hair Follicle Stem Cells
January 2017
in “
Seoul National University Open Repository (Seoul National University)
”
Aminoacyl-tRNA synthetase interacting multifunctional protein 1 AIMP1 CD34+ hair follicle stem cells dermal papilla cells sonic hedgehog signaling Shh wnt signaling pathway sFRP1 N-terminal fragment of AIMP1 therapeutic peptide alopecia carbomer hair follicle stem cells hair loss hair growth topical treatment
TLDR AIMP1 can boost hair growth by increasing stem cell activity.
The study investigated the role of Aminoacyl-tRNA synthetase interacting multifunctional protein 1 (AIMP1) in hair follicle stem cell proliferation and its potential as a treatment for hair loss. AIMP1, when dissociated from the multi-tRNA synthetase complex, was found to be secreted by dermal papilla cells in a sonic hedgehog (Shh) signal-dependent manner. This secretion increased the proliferation of CD34+ hair follicle stem cells by promoting the wnt signaling pathway through inhibition of sFRP1, a known wnt antagonist. The study demonstrated that the N-terminal fragment of AIMP1 could be developed into a therapeutic peptide for alopecia. When applied topically to depilated mice, this peptide significantly accelerated hair growth, especially when formulated with carbomer. These findings highlighted a novel mechanism of AIMP1 and its potential application in treating hair loss.
