Low-Dose Systemic Methotrexate Therapy for Recalcitrant Alopecia Areata

    January 2017 in “ Annals of Dermatology ”
    Seul-Ki Lim, Cho-Ah Lim, In Sun Kwon … Young Lee
    Studysummary In this retrospective study, low-dose methotrexate was observed to be effective and well-tolerated in treating recalcitrant alopecia areata multiplex, achieving complete or near-complete hair regrowth in about 90% of patients despite some experiencing elevated liver enzymes and gastrointestinal discomfort.
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    Research cited in this study 9

    1. Comparison of High-Dose Corticosteroid Pulse Therapy and Combination Therapy Using Oral Cyclosporine with Low-Dose Corticosteroid in Severe Alopecia Areata Annals of dermatology/Annals of Dermatology · 2015
    2. Efficacy and Safety of Methotrexate in Alopecia Areata Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2014
    3. The Effect of Oral Cyclosporine in the Treatment of Severe Alopecia Areata Cutaneous and ocular toxicology · 2013
    4. Pulse Corticosteroid Therapy for Alopecia Areata in Children: A Retrospective Study Dermatology · 2013
    5. Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series Dermatology · 2012
    6. Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2011
    7. Treatment of Severe Alopecia Areata with Intralesional Steroid Injections PubMed · 2009
    8. A Comparison of the Efficacy, Relapse Rate, and Side Effects Among Three Modalities of Systemic Corticosteroid Therapy for Alopecia Areata Dermatology · 2006
    9. Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata Journal of the American Academy of Dermatology · 2005

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    1. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019