N1-Acetylspermidine Is a Determinant of Hair Follicle Stem Cell Fate

May 2021 in “ Journal of Cell Science ”

Kira Allmeroth, Christine S. Kim, Andrea Annibal, Andromachi Pouikli, Janis Koester, Maxime Derisbourg, Carlos Andrés Chacón‐Martínez, Christian Latza, Adam Antebi, Peter Tessarz, Sara A. Wickström, Martin S. Denzel

TLDR N1-acetylspermidine promotes hair follicle stem cell self-renewal.

The study explored the role of polyamines in hair follicle stem cell (HFSC) fate decisions, focusing on the translation-independent effects of polyamines. Researchers found that HFSCs had lower translation rates and polyamine levels compared to progenitor cells. While overall polyamine depletion decreased translation without affecting cell fate, specific depletion through SSAT activation enhanced stemness without reducing translation. N1-acetylspermidine was identified as a key determinant of cell fate, promoting self-renewal and showing increased levels during HFSC proliferation and differentiation in vivo. The findings highlighted the complex role of polyamine metabolism in regulating stem cell fate.

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