Different Synaptic Stimulation Patterns Influence Local Androgenic and Estrogenic Neurosteroid Availability Triggering Hippocampal Synaptic Plasticity in Male Rats

    February 2017 in “ European journal of neuroscience/EJN. European journal of neuroscience ”
    Michela Di Mauro, Alessandro Tozzi, Paolo Calabresi … Silvia Grassi
    Studysummary This study found that local synthesis of 17β-estradiol and 5α-dihydrotestosterone, combined with specific stimulation patterns, is crucial in determining the direction and strength of long-term synaptic effects in the hippocampal CA1 region of male rat slices.
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    Research cited in this study 2

    1. Neo-Synthesis of Estrogenic or Androgenic Neurosteroids Determine Whether Long-Term Potentiation or Depression Is Induced in Hippocampus of Male Rat Frontiers in Cellular Neuroscience · 2015
    2. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006