65 citations
,
February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This paper discusses the hypothesis that anti-acne agents may work by reducing FGFR2 signaling, and emphasizes FGFR2's potential role in acne pathogenesis, but it reports no new experimental findings.
60 citations
,
January 2023 in “Biomaterials Science” This study reviews recent advancements in microneedles made from PLGA, highlighting their use in delivering vaccines, drugs, and proteins through the skin with minimal invasiveness, and discusses the challenges and future potential of these delivery systems.
60 citations
,
December 2020 in “Stem Cell Research & Therapy” In this laboratory study, ASC-conditioned medium showed higher therapeutic potential than extracellular vesicles alone in reducing inflammation and catabolic activity in human chondrocytes with an osteoarthritis phenotype, highlighting its possible use in osteoarthritis management.
57 citations
,
May 2016 in “Matrix Biology” This study found that the absence of laminin α5 in adult mice's epidermal basement membrane led to keratinocyte hyperproliferation and immune cell changes, affecting hair follicle development through altered growth factor expression.
56 citations
,
August 1994 in “PubMed” This study found that prolactin and melatonin both stimulated hair shaft elongation in Cashmere goat hair follicles, with maximum growth observed at specific concentrations, although melatonin reduced follicle viability after 96 hours.
52 citations
,
April 2013 in “Developmental Cell” This study found that Brg1, a chromatin-remodeling enzyme, plays a critical role in hair regeneration and early epidermal repair by regulating bulge stem cells through a Brg1-Shh interaction.
50 citations
,
May 2011 in “Journal of Ethnopharmacology” In this cell study, Eclipta alba extract inhibited cancer cell proliferation and induced apoptosis, showing potential antiproliferative and anti-metastasis effects on liver and related cancer cell lines.
48 citations
,
May 2008 in “Drug Discovery Today: Disease Mechanisms” This review discusses recent advancements in understanding hair follicles, their disorders, and potential therapeutic opportunities, but it reports no new clinical findings.
45 citations
,
November 2022 in “Acta Biomaterialia” This study developed a biomimetic 3-D co-culture system that enhances the hair-inductive properties of human dermal papilla cell aggregates, potentially improving hair follicle tissue engineering.
42 citations
,
February 2000 in “Journal of Investigative Dermatology” This study found that Gelatinase A activity is linked to the absence of type VII collagen during human fetal skin development, indicating its role in remodeling the basement membrane zone.
40 citations
,
February 2020 in “Experimental and Therapeutic Medicine” This study found that autologous serum platelet-rich plasma improved skin quality and reduced wrinkles, texture, and pores in healthy females, partly by regulating the expression of MMP-1, tyrosinase, fibrillin, and tropoelastin.
38 citations
,
May 2010 in “American Journal Of Pathology” In this study, prolonged systemic administration of 17β-estradiol in castrated male mice delayed wound healing by inhibiting re-epithelialization and reducing collagen accumulation, with estrogen receptor-α likely mediating this effect.
36 citations
,
May 2016 in “Biomaterials” This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.
34 citations
,
January 2018 in “International Journal of Dermatology” This review discusses chemotherapy-induced alopecia, highlighting its pathogenesis, clinical patterns, and current therapeutic approaches, with no new clinical results reported.
34 citations
,
August 1966 in “Experimental cell research” This study examined developing hair cortex with electron microscopy and found that keratin fibrils form between specific regions in hair follicles and aggregate into twisted cables.
32 citations
,
January 2005 in “Advances in Biochemical Engineering / Biotechnology” This review discusses the unique capacity of fetal skin to heal wounds without scarring and notes that while many factors have been identified, the complete mechanism of fetal wound healing remains unclear.
30 citations
,
October 2010 in “Biochemical and biophysical research communications” This study found that the Gsdma3 gene is necessary for normal hair follicle differentiation in mice, with its mutation leading to progressive hair loss and defects in hair structure.
30 citations
,
November 2018 in “EMBO Reports” This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.
30 citations
,
April 2009 in “Mycoses” This study found that the fungus Microsporum gypseum enzymatically degrades keratin in human hair, with the sequence of degradation reflecting the keratinization and cystine content of individual hair components in vitro.
29 citations
,
January 2016 in “Annals of dermatology/Annals of Dermatology” This study found that arachidonic acid may promote hair growth by enhancing dermal papilla cell function and stimulating the anagen phase in C57BL/6 mice.
27 citations
,
July 2020 in “Stem Cells International” This study observed that while PRP therapy increased inflammation and fibrosis in photoaged skin, ADSCs therapy showed promising antiaging effects by promoting elastin and fibrillin formation and remodeling the dermis.
27 citations
,
September 2015 in “Drug Design Development and Therapy” This study suggests that type IV collagenases, MMP-2 and MMP-9, play important roles in the hair cycle by regulating the expression of VEGF, IGF-1, and TGF-β in mice.
27 citations
,
August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified 12 new genes associated with the hair follicle and various stages of the hair cycle in mice, which could lead to novel targets for hair growth or depilation therapies.
27 citations
,
June 2001 in “International Journal of Dermatology” This study found that cytokine and EGF stimulation leads to increased MMP-9 production in hair follicles, a process involved in hair follicle involution associated with alopecia.
25 citations
,
December 2021 in “Stem Cell Research & Therapy” This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.
25 citations
,
April 2021 in “The EMBO Journal” This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.
25 citations
,
June 2018 in “Journal of The American Academy of Dermatology” This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.
25 citations
,
July 2008 in “British Journal of Dermatology” This study observed dynamic changes in CD10 and CD34 expression in fetal and adult human hair follicles during embryogenesis and hair cycling.
24 citations
,
January 2016 in “Lasers in Medical Science” This study found that non-ablative fractional erbium glass laser treatment affected gene regulation in human skin models by downregulating MMP and interleukin expression, suggesting potential roles in dermal remodeling and anti-inflammatory effects.
23 citations
,
June 2016 in “FEBS Journal” The study found that up-regulating β-catenin signaling in CD 133-positive dermal papilla cells enhanced their ability to promote hair follicle regeneration both in vitro and in vivo.