An Ovol2-Zeb1 Transcriptional Circuit Regulates Epithelial Directional Migration and Proliferation

    November 2018 in “ EMBO Reports ”
    Daniel Haensel, Peng Sun, Adam L. MacLean … Xing Dai
    Studysummary This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.
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    Research cited in this study 13

    1. Epithelial-To-Mesenchymal Transition in Cutaneous Wound Healing: Where We Are and Where We Are Heading Developmental Dynamics · 2017
    2. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
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    5. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    6. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    7. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    8. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    9. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    10. Wound Repair at a Glance Journal of Cell Science · 2009
    11. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    12. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    13. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005