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GlossaryMAPK pathway inhibitors

drugs that block cell growth and survival signaling pathways

MAPK pathway inhibitors are drugs that block the Mitogen-Activated Protein Kinase (MAPK) pathway, a critical signaling pathway that regulates cell growth, division, and survival. By inhibiting this pathway, these drugs can help treat conditions like cancer and certain types of alopecia, where abnormal cell growth or survival is a problem.

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research Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons

10 citations , March 2018 in “Chemosphere”

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

research LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway

53 citations , April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

research Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias

10 citations , December 2018 in “Medical Science Monitor”

Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology

research Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology

26 citations , October 2018 in “Clinical & Translational Oncology”

Spanish experts provided guidelines for treating skin side effects in cancer patients on new therapies, stressing early action and teamwork.

research Module-based complexity formation: periodic patterning in feathers and hairs

47 citations , May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology”

The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.

research Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress

43 citations , August 2016 in “International Journal of Nanomedicine”

Eupafolin nanoparticles help protect skin cells from damage caused by air pollution.

Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , January 2006 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis

29 citations , April 2019 in “Acta neuropathologica communications”

Stopping mitochondrial respiration can prevent brain cancer spread in skin cancer patients, and plant compound β-sitosterol could help achieve this.

ERK1/2 Pathway Is Involved in the Enhancement of Fatty Acids from Phaeodactylum tricornutum Extract (PTE) on Hair Follicle Cell Proliferation

research ERK1/2 Pathway Is Involved in the Enhancement of Fatty Acids from Phaeodactylum tricornutum Extract (PTE) on Hair Follicle Cell Proliferation

2 citations , October 2020 in “BioMed Research International”

Phaeodactylum tricornutum extract helps hair follicle cells grow by activating the ERK1/2 pathway.

research The Hair Follicle as an Estrogen Target and Source

159 citations , July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis

106 citations , December 2016 in “Cell Stem Cell”

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

research Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation

65 citations , June 2003 in “EMBO journal”

Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.

research Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK—ERK Signaling Pathway

45 citations , September 2014 in “Cell Transplantation”

Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.

Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion

research Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion

30 citations , December 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

research Human placental extract exerts hair growth-promoting effects through the GSK-3β signaling pathway in human dermal papilla cells

20 citations , August 2015 in “International Journal of Molecular Medicine”

Human placental extract may help hair growth by affecting certain cell signals and could be more effective with minoxidil.

research Effects of dihydrotestosterone on rat dermal papilla cells in vitro

19 citations , June 2015 in “European Journal of Pharmacology”

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Acne

4 citations , January 2019

Acne is a common skin condition that can be influenced by diet, lifestyle, and hormones, and requires a treatment approach that includes psychological considerations.

research Montagna Symposium 2017—Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment

1 citations , June 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

The symposium highlighted the importance of understanding disease mechanisms for targeted dermatology treatments.

research Metabolic Teamwork in the Stem Cell Niche

14 citations , May 2017 in “Cell metabolism”

Paneth cells and intestinal stem cells work together metabolically for stem cell function and regeneration.

4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , July 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis

1 citations , March 2023 in “Science Translational Medicine”

Blocking a certain signal in the gp130 receptor can improve tissue healing and lessen osteoarthritis symptoms.

research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

695 citations , October 2011 in “Cell stem cell”

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

research Therapeutics for COVID-19 and post COVID-19 complications: An update

52 citations , January 2022 in “Current Research in Pharmacology and Drug Discovery”

New treatments for COVID-19 show promise, but more effective antiviral drugs are needed.

research Toward a Unifying Hypothesis for Redesigned Lipid Catabolism as a Clinical Target in Advanced, Treatment-Resistant Carcinomas

September 2023 in “International journal of molecular sciences”

Targeting lipid metabolism can help treat advanced, resistant cancers.

research The effects of GPR40 agonists on hair growth are mediated by ANGPTL4

May 2023 in “Biomedicine & Pharmacotherapy”

GPR40 agonists help hair growth through the protein ANGPTL4.

research The Molecular Mechanism of Natural Products Activating Wnt/β-Catenin Signaling Pathway for Improving Hair Loss

November 2022 in “Life”

research The Molecular Mechanism Underlying the Proliferating and Preconditioning Effect of Vitamin C on Adipose-Derived Stem Cells

42 citations , June 2014 in “Stem Cells and Development”

Vitamin C helps adipose-derived stem cells grow and may support hair growth.

research Tfap2b specifies an embryonic melanocyte stem cell that retains adult multi-fate potential

June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.

research Understanding, recognizing, and managing toxicities of targeted anticancer therapies

278 citations , May 2013 in “Ca”

Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.