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GlossaryMAPK pathway inhibitors

drugs that block cell growth and survival signaling pathways

MAPK pathway inhibitors are drugs that block the Mitogen-Activated Protein Kinase (MAPK) pathway, a critical signaling pathway that regulates cell growth, division, and survival. By inhibiting this pathway, these drugs can help treat conditions like cancer and certain types of alopecia, where abnormal cell growth or survival is a problem.

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research LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway

53 citations, April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

Clinical Management of Cutaneous Adverse Events in Patients on Targeted Anticancer Therapies and Immunotherapies: A National Consensus Statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology

research Clinical Management of Cutaneous Adverse Events in Patients on Targeted Anticancer Therapies and Immunotherapies: A National Consensus Statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology

26 citations, October 2018 in “Clinical & Translational Oncology”

Spanish experts provided guidelines for treating skin side effects in cancer patients on new therapies, stressing early action and teamwork.

research Eupafolin Nanoparticles Protect HaCaT Keratinocytes from Particulate Matter-Induced Inflammation and Oxidative Stress

43 citations, August 2016 in “International Journal of Nanomedicine”

Eupafolin nanoparticles help protect skin cells from damage caused by air pollution.

research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution, And Tumor-Initiating Cells

37 citations, November 2017 in “Medical Sciences”

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

research Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

403 citations, December 2018 in “Cell stem cell”

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 120 upvotes 6 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 7 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.