Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias

    December 2018 in “ Medical Science Monitor ”
    Nini An, Jinpu Peng, Guoqing He, Xia Fan, Fei Li, H. S. Chen
    TLDR The MAPK/ERK pathway is crucial in controlling cell growth and death in finasteride-induced hypospadias.
    The study investigated the role of the MAPK/ERK signaling pathway in finasteride-induced hypospadias in rats. Researchers established a hypospadias model using finasteride and confirmed it through HE staining. Urethral plate fibroblasts (UPFs) from normal and modeled rats were analyzed for proliferation, apoptosis, and cell cycling. Results showed that finasteride increased UPF proliferation and cell cycling while reducing apoptosis. Inhibitors of MAPK and ERK mitigated these effects. The study concluded that the MAPK/ERK pathway played a significant role in regulating UPF proliferation, apoptosis, and cell cycling in finasteride-induced hypospadias.
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