21 citations
,
October 1988 in “Clinics in Dermatology” This study found that topical minoxidil induced hair regrowth in stumptailed macaques, with more significant effects observed in younger animals, while cessation led to renewed balding and retreatment restored regrowth.
18 citations
,
April 1986 in “International Journal of Cosmetic Science” In this study with stumptailed macaques, topical minoxidil successfully induced hair regrowth on bald scalps and prevented baldness on non-bald scalps, with no observed side effects over nearly three years.
January 2000 in “Hair and its disorders: biology, pathology and management, 2000, ISBN 1853177997, págs. 137-152”
13 citations
,
April 1994 in “Journal of Investigative Dermatology” Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
34 citations
,
December 1991 in “Annals of the New York Academy of Sciences” The conclusion is that small hair follicles cause baldness in macaques, and treatments like antiandrogens and minoxidil can prevent hair loss and promote regrowth.
8 citations
,
October 1988 in “Clinics in dermatology” This paper discusses the lack of a genetic model for androchronogenic alopecia in rodents, noting the stumptailed macaque as a better current model due to its similarities to human male-pattern baldness; it reports no new results.
27 citations
,
October 1999 in “Experimental and Molecular Pathology” This article reviews potential animal models for studying androgenetic alopecia and reports no new experimental results; the authors highlight the need for further development of rodent models.
6 citations
,
August 2001 in “PubMed” This review discusses the suitability of stump-tailed macaques and rodent models for studying hair growth and developing treatments for androgenetic alopecia, but reports no new experimental results.
5 citations
,
February 2011 in “Expert Opinion on Drug Discovery” This review discusses techniques and models for assessing hair growth activity but reports no new clinical findings, emphasizing the need for standardization and improved animal models.
1 citations
,
January 1997 in “Journal of Investigative Dermatology” In this study using a macaque model, RU58841 at a 5% concentration significantly increased hair density, thickness, and length in the frontal bald scalp over six months.
25 citations
,
September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology” This study concludes that rhesus macaques are a suitable model for testing the pharmacological properties of finasteride and other 5aR inhibitors, due to their biochemical similarity to humans.
This study found that a high-fat diet in macaques led to severe gastrointestinal inflammation and chronic wasting, with more pronounced effects in females, highlighting the potential risks of certain dietary interventions in obesity models.
33 citations
,
January 2002 This study found that daily topical application of 500 microg/ml latanoprost led to moderate to marked hair regrowth in a macaque model of androgenetic alopecia.
This study found that social hair plucking in captive rhesus macaques was associated with alopecia and exhibited patterns similar to both prosocial and aggressive behaviors.
11 citations
,
May 1990 in “Journal of Dermatological Science” In this animal study, topical diazoxide treatment led to increased hair thickness and follicle growth in bald stumptailed macaques without causing notable systemic side effects.
11 citations
,
October 1994 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.
12 citations
,
October 1988 in “Clinics in dermatology” This report introduces a mouse model with androgen-dependent alopecia, suggesting it as a potential alternative for studying hair loss mechanisms and testing treatments.
32 citations
,
January 1994 in “Skin Pharmacology and Physiology” In this study, scalp skin from stumptailed macaques demonstrated minoxidil sulfotransferase activity primarily in hair follicles, which may explain minoxidil's hair growth stimulation in this model.
23 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that topical minoxidil and diazoxide induced significant hair regrowth in bald macaques, while a steroid 5 alpha-reductase inhibitor prevented baldness in preadolescent macaques.
August 2018 in “Journal of Investigative Dermatology” This study found that humans have a much higher eccrine gland density than chimpanzees and macaques, suggesting a unique evolutionary path for human skin features.
7 citations
,
January 1989 Minoxidil and 4-MA can help treat hair loss.
22 citations
,
April 2015 in “Current problems in dermatology” Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
8 citations
,
January 2001 in “Methods in enzymology on CD-ROM/Methods in enzymology” This article discusses methods to evaluate hair growth stimulants and reports no new clinical results; the authors highlight the need for more precise identification of stem cell sites in hair follicles.
15 citations
,
January 2020 in “ILAR Journal” This review discusses the occurrence and impact of background histopathologic changes in nonhuman primate research, emphasizing the importance of understanding these factors to enhance study validity and interpretation.
38 citations
,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
1 citations
,
March 2021 in “Skin health and disease” This review evaluates laboratory models used in androgenetic alopecia research but reports no new findings, emphasizing the potential of human-derived 3-D models for future studies.
54 citations
,
June 1985 in “American Journal of Dermatopathology” This abstract does not provide specific findings or results.
82 citations
,
March 2016 in “Autoimmunity reviews” This review explores animal models of alopecia areata, particularly focusing on the insights they've provided into the disease's immune mechanisms and potential treatment approaches, without reporting new experimental data.
36 citations
,
October 1996 in “Dermatologic Clinics” In this study, a methanol extract of Eclipta alba was found to have dose-dependent hair growth-promoting activity in C57BL6 mice.
76 citations
,
August 2018 in “International Journal of Cosmetic Science” This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.