61 citations,
June 2016 in “Clinical Medicine” PCOS is often linked to insulin resistance and obesity, and weight loss can improve symptoms.
53 citations,
October 1993 in “Drug Safety” Oral retinoids can cause side effects ranging from mild to severe, including birth defects, and require careful monitoring and contraception.
32 citations,
January 2006 in “Liver transplantation” Vitamin A toxicity can cause severe health issues and may require a liver transplant if other treatments fail.
21 citations,
June 1990 in “British Journal of Dermatology” Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.
17 citations,
January 2020 in “The World Journal of Men's Health” Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.
7 citations,
February 2015 in “Journal of comparative pathology” CD8+ T cells play a key role in graft-versus-host disease in certain mice models.
6 citations,
May 2020 in “Pharmacology Research & Perspectives” A new gel form of minoxidil is equally effective for hair growth and safer for the heart and other organs than the traditional solution.
5 citations,
December 2005 in “Clinical Techniques in Equine Practice” Skin and hair changes in horses can indicate serious diseases, and recognizing these signs is important for treatment and management.
1 citations,
June 2022 in “JCRPE” Metreleptin treatment significantly improved metabolic health in a boy with congenital generalized lipodystrophy.
January 2024 in “International Journal of Dermatology Venereology and Leprosy Sciences” Patients with acne vulgaris have lower serum irisin levels.
August 2023 in “Gadua Journal of Pure and Allied Science” Ziziphus spina-christi leaf extract lowered blood sugar and protected organs in diabetic rats.
January 2023 in “Integrative Journal of Medical Sciences” A young Saudi girl with uncontrolled type 1 diabetes and hypothyroidism had two rare conditions, Mauriac syndrome and Van Wyk–Grumbach syndrome.
February 1999 in “Strength and Conditioning Journal” Androstenedione, a hormone supplement, doesn't improve muscle or performance and can cause harmful side effects.
September 2012 in “International Current Pharmaceutical Journal” CHOP chemotherapy causes many side effects but is generally well tolerated.
299 citations,
January 2018 in “Journal of Clinical Investigation” Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
232 citations,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
208 citations,
July 2001 in “Journal of The American Academy of Dermatology” Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.
204 citations,
October 1999 in “EMBO journal” Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.
165 citations,
October 2013 in “Nature Communications” Scientists made working salivary glands in mice using bioengineered cells, which could help treat dry mouth.
155 citations,
August 1991 in “Journal of The American Academy of Dermatology” Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
138 citations,
November 2015 in “Journal of Pharmacology and Experimental Therapeutics” Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.
127 citations,
January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
126 citations,
October 1983 in “Journal of The American Academy of Dermatology” Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.
113 citations,
December 2000 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” KGF and activin are crucial for skin healing and repair.
76 citations,
September 1992 in “Endocrinology” The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.
75 citations,
October 1999 in “European journal of endocrinology” Finasteride is a safe, effective treatment for hirsutism with fewer side effects.
69 citations,
June 2017 in “Experimental Biology and Medicine” Advanced human skin models improve drug development and could replace animal testing.
60 citations,
June 2019 in “Ageing Research Reviews” Fat from the body can help improve hair growth and scars when used in skin treatments.
55 citations,
July 1999 in “Clinics in Sports Medicine” Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.
44 citations,
April 2012 in “American Journal of Clinical Dermatology” Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.