A Rare Association of Mauriac Syndrome and Van Wyk-Grumbach Syndrome in a Young Saudi Girl with Poorly Controlled Type 1 Diabetes and Hypothyroidism: A Case Report and Brief Literature Review
January 2023
in “
Integrative Journal of Medical Sciences
”
hypothyroidism type 1 diabetes mellitus T1DM Mauriac syndrome Van Wyk–Grumbach syndrome hyperlipidemia cushingoid features growth retardation hepatomegaly glycogenic hepatopathy multicystic ovaries uterine bleeding delayed bone age anti-TPO antibodies diabetes thyroid disease liver enlargement high cholesterol delayed puberty autoimmune thyroid antibodies
TLDR A young Saudi girl with uncontrolled type 1 diabetes and hypothyroidism had two rare conditions, Mauriac syndrome and Van Wyk–Grumbach syndrome.
This case report describes a young Saudi girl with poorly controlled type 1 diabetes mellitus (T1DM) and hypothyroidism who presented with two rare complications: Mauriac syndrome and Van Wyk–Grumbach syndrome. Mauriac syndrome is characterized by symptoms such as elevated liver enzymes, hyperlipidemia, cushingoid features, growth retardation, and hepatomegaly due to glycogenic hepatopathy, while Van Wyk–Grumbach syndrome is characterized by symptoms such as breast development, multicystic ovaries, uterine bleeding, lack of pubic and axillary hair growth, and delayed bone age. These complications are associated with long-standing, uncontrolled T1DM and untreated hypothyroidism, respectively. The report highlights the increased risk of hypothyroidism in children with T1DM, with 9.6% having hypothyroidism and 19% having positive anti-TPO antibodies, and emphasizes the importance of controlling diabetes to prevent such complications.
