A Clinical and Histopathological Study of Cicatricial Alopecia

    July 2013 in “ Our Dermatology Online ”
    Neerja Puri, Asha Puri
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    TLDR Lichen planopilaris is the most common type of scarring hair loss observed, with a variety of symptoms and tissue changes.
    In the 2013 study of 40 patients, researchers found that lichen planopilaris (LPP) was the most prevalent form of cicatricial alopecia, followed by discoid lupus erythematosus (DLE) and pseudopelade of Brocq. The majority of the patients were female, with a 1.5:1 female to male ratio, and 70% had multiple patches of hair loss. Clinically, 90% showed epidermal atrophy, 55% had erythema, and 40% displayed follicular plugging. Histopathological examination revealed that 65% had perifollicular fibrosis, 52.5% showed basal cell vacuolization, and 50% had perifollicular lymphocytic infiltrate. The study concluded that there is a variety of clinical and histopathological presentations for cicatricial alopecia, with LPP, DLE, and pseudopelade of Brocq being the most frequently observed types.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  98 upvotes 1 month ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  57 upvotes 2 weeks ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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