Clinicopathological Features of Alopecia With an Emphasis on Etiology and Histopathological Characteristics of Scarring Alopecia

    August 2022 in “ Cureus ”
    Atif Ali Hashmi, Khushbakht Rashid, Rubia Ali, Tanim Ud Dowlah, Abrahim H Ali, Muhammad Asad Diwan, Umair Arshad Malik, M. Irfan, Shamail Zia, A.L. Ahmad
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    TLDR Scarring alopecia, a type of hair loss, is most common in females under 35, often caused by discoid lupus erythematosus and pseudopelade of Brocq. Skin punch biopsy and histopathology are key to identifying its cause.
    The research conducted at the Department of Histopathology, Liaquat National Hospital and Medical College, Pakistan, involved 104 patients and found that scarring alopecia was the most common type of hair loss, accounting for 88.5% of cases. It was more prevalent among females (73.1%) and individuals under 35 years old (53.8%). The most common causes were discoid lupus erythematosus and pseudopelade of Brocq, each accounting for 23.1% of cases, followed by lichen planopilaris (15.4%). The study emphasized the importance of skin punch biopsy and histopathology in accurately determining the cause of scarring alopecia. However, the study had limitations including single institution data, lack of treatment response observation, and lack of patient follow-up.
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