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In this study, researchers found that glycan profiles in epidermal stem cells differed between young and old mice, suggesting these changes may serve as molecular markers for aging.

This study observed that lectin-binding patterns in skin appendage tumors reveal differences in sweat gland tumors compared to normal tissues, but pilosebaceous tumors maintained a similar lectin-binding pattern to their corresponding normal structures.

This review discusses the role of leptin in skin biology and pathology, highlighting its potential in enhancing skin regeneration, hair cycle progression, and wound healing, but reports no new clinical results.

This study found that leptin acts as an inducer of the anagen phase in hair follicles, suggesting its role as a potential player in hair biology.

This study found that human follicular papilla cells in the scalp produce leptin and express functional leptin receptors, suggesting leptin's significant role in hair biology.

This study found that leptin from dermal white adipose tissue may regulate hair growth and cycle progression through its receptor on hair follicle epithelium in mice and humans.

Leptin helps start the growth phase of hair.

In this study, HIIT increased adiponectin levels and improved cholesterol profiles in women with PCOS, but did not change leptin or vaspin levels.

In this study, isotretinoin treatment for acne vulgaris significantly increased serum adiponectin and leptin levels but had no significant effect on BMI or ghrelin levels.

This review explores the current understanding of leptin's role in psoriasis and other skin diseases but reports no new clinical findings, emphasizing that the exact mechanisms of its impact are still being investigated.

This review discusses leptin's regulatory roles in the progression of various dermatological diseases and reports no new clinical results, highlighting a complex relationship still under investigation.

This review discusses mechanisms of wound healing impairment in leptin-deficient murine models used for diabetic research, and reports no new clinical results; the authors emphasize the need for further study.

This study found that men with androgenetic alopecia had significantly higher plasma leptin levels, which were associated with an increased risk of developing the condition.

This study found that adipokines were expressed in the epidermis, hair follicles, sebocytes, apocrine glands, and vascular endothelium of normal canine skin, but not in the dermis or hypodermis.

This case study suggests that low leptin levels in obese hyperandrogenic postmenopausal women might indicate the presence of androgen-secreting tumors.

This pilot study found elevated levels of leptin and other proinflammatory molecules in the serum of melanoma patients, suggesting a potential role for leptin in melanoma progression and a possibility for targeting it in adjuvant therapy.

This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.

Women with idiopathic hirsutism and PCOS have higher RBP4 levels, and PCOS is linked to greater insulin resistance; weight management may help both conditions.

This study found that intravenous administration of a shark-derived receptor antibody, 3P17, promoted hair growth in mice by increasing hair matrix cell proliferation and activating leptin-STAT3 signaling, with transdermal leptin delivery enhancing this effect through improved skin penetration.

This study found that patients with alopecia areata had lower adiponectin levels and higher leptin levels compared to healthy controls, with leptin levels correlating positively with insulin resistance markers and negatively with HDL cholesterol.

This study found that curcumin supplementation in adults significantly increased serum adiponectin levels and decreased leptin levels, based on a meta-analysis of 13 randomized controlled trials.

This study suggests that specific mutations in the MFN2 gene, including the p.Arg707Trp allele, can result in tissue-selective mitochondrial dysfunction leading to excessive upper body fat growth and low leptin levels.

In this study, PSA levels were significantly lower among African-American men with higher C-peptide levels and Caucasian men with higher HbA1c levels, suggesting a link between metabolic markers and prostate cancer detection.

This study identified significant differences in cytokine levels between people with primary cicatricial alopecias and unaffected individuals, suggesting cytokines may play a role in the condition's autoimmune nature and management.

In this study, higher plasma leptin levels were associated with increased risk and severity of androgenetic alopecia in men, but further research is needed to understand the clinical implications.

This study found that incorporating Canavalia ensiformis lectin into alginate and carboxymethylcellulose films enhanced angiogenic factor expression, suggesting these biopolymer films could be an effective alternative for wound treatment.

In this study, the immunohistochemical and lectin binding profiles of basal cell carcinoma closely resembled those of the outer root sheath of vellus hair follicles, suggesting a potential histochemical relationship.

This review explores the phytochemistry and phytopharmacology of Urtica dioica but reports no new experimental findings, focusing on its traditional uses and range of bioactive constituents.

This study found that testosterone therapy improved physical performance and strength in older men with low testosterone over 36 months, whether administered alone or with finasteride.