The Effect of Curcumin Supplementation on Circulating Adiponectin and Leptin Concentration in Adults: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials

    November 2023 in “ British journal of nutrition ”
    Vali Musazadeh, Shaghayegh Abbasi, Zeynab Kavyani, Amir Hossein Moridpour, Diba Safarzadeh, Zahra Moradi, Fatemeh Bahadori, Amir Hossein Faghfouri
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    TLDR Curcumin supplements increase adiponectin and decrease leptin in adults.
    This systematic review and meta-analysis of 13 randomized controlled trials (RCTs) with 14 treatment arms investigated the effects of curcumin supplementation on serum adiponectin and leptin levels in adults. The results showed that curcumin significantly increased serum adiponectin (SMD = 0.86, 95% CI [0.33, 1.39], P < 0.001) and decreased serum leptin (SMD = -1.42, 95% CI [-2.29, -0.54], P < 0.001). These findings suggest that curcumin supplementation can beneficially modulate these adipokines, which are involved in inflammation and metabolic processes.
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