Association Between PSA and Leptin, Adiponectin, HbA1c, or C-Peptide Among African-American and Caucasian Men

    November 2007 in “ Cancer Epidemiology and Prevention Biomarkers ”
    Jay H. Fowke, Charles Matthews, Maciej S. Buchowski, Lisa Signorella, Sam K. C. Chang, Michael S. Cookson, William J. Blot
    TLDR Higher C-peptide levels in African-American men and higher HbA1c levels in Caucasian men are linked to lower PSA levels.
    This study investigated the association between prostate-specific antigen (PSA) levels and obesity-related biomarkers in 121 African-American (AA) and 121 Caucasian (CA) men. It found that among AA men, higher C-peptide levels were associated with approximately 50% lower PSA levels, particularly in those with a BMI of 30 or more. Among CA men, higher HbA1c levels were linked to similarly reduced PSA levels. No significant associations were found between PSA and leptin or adiponectin levels in either group. The study suggested that metabolic disturbances related to metabolic syndrome, insulin activity, or diabetes might impact the detection of early-stage prostate cancer, highlighting the need for further research into race-specific relationships involving steroid hormones, insulin activity, obesity, and PSA.
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