Systemic Circulating Leptin: Aiding New Dimension of Immune-Related Skin Carcinogenesis and Lipid Metabolism

This study explores the role of leptin, a pleiotropic adipocytokine, in melanoma skin cancer, particularly in the context of obesity-related chronic inflammation. Using protein microarray technology, the researchers analyzed serum from melanoma patients and healthy volunteers, finding elevated levels of proinflammatory molecules, including leptin, in melanoma patients. The study highlights that high leptin levels correlate with advanced melanoma stages and other inflammatory markers, suggesting leptin's involvement in promoting inflammation and tumorigenesis. The findings propose that leptin-based therapeutic approaches could offer new avenues for adjuvant therapy in skin cancers.