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research 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment

April 2017 in “Journal of Investigative Dermatology”

This study found that SM04755, a novel topical drug, inhibited inflammation, keratinocyte proliferation, and fibrosis in vitro and improved skin health in a mouse model of psoriasis, indicating potential as a topical psoriasis treatment.

research Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective

188 citations , February 2023 in “International Journal of Molecular Sciences”

This review compiled evidence suggesting that flavonoids may promote skin wound healing due to their anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant properties, while also discussing current limitations and future prospects for these compounds as wound-healing agents.

research Systemic Circulating Leptin – Aiding New Dimension of Immune-Related Skin Carcinogenesis and Lipid Metabolism

2 citations , April 2023 in “South East European Journal of Immunology”

This pilot study found elevated levels of leptin and other proinflammatory molecules in the serum of melanoma patients, suggesting a potential role for leptin in melanoma progression and a possibility for targeting it in adjuvant therapy.

research Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

81 citations , March 2022 in “Frontiers in Bioengineering and Biotechnology”

This review discusses advancements and challenges in bioengineered scaffolds for wound healing but presents no new experimental findings, highlighting their potential and need for further development.

research Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis

1 citations , March 2023 in “Science Translational Medicine”

The researchers reported that targeting glycoprotein 130's signaling site in animal models promoted tissue regeneration and reduced osteoarthritis progression through anti-inflammatory and protective effects.

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community Microneedling aftercare advice

4 upvotes 4 years ago

Microneedling aftercare involves using saline water instead of sea water, and avoiding hyaluronic acid due to its potential pro-inflammatory effects. Users suggest using jojoba oil as a carrier for essential oils like rosemary and lavender, and combining microneedling with minoxidil for better hair regrowth results.

community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Dutasteride vs Finasteride and Steroid

in Progress Pictures 87 upvotes 11 months ago

Dutasteride is preferred over finasteride for hair loss due to fewer side effects. Combining dutasteride with minoxidil and RU58841 is effective for hair regrowth, even during steroid use.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

44 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

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