research Analysis of 72,469 UK Biobank Exomes Links Rare Variants to Male-Pattern Hair Loss
Rare genetic variants in five specific genes are linked to male-pattern hair loss but only account for a small part of the risk.
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930-960 / 1000+ results research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.
research Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production
Hair color is determined by melanin produced and transferred in hair follicles.
research Spermidine/Spermine-N1-Acetyltransferase: A Key Metabolic Regulator
SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.
research Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
TNFα helps grow and maintain liver cells in 3D culture for a long time.
research Quiescent Tissue Stem Cells Evade Immune Surveillance
Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.
research Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System
Cannabinoids may help treat various skin conditions.
research Frizzled Receptors in Development and Disease
Frizzled receptors are essential for various body development processes and maintaining certain body functions.
research Cell Fate Decisions: Emerging Roles for Metabolic Signals and Cell Morphology
Metabolic signals and cell shape influence how cells develop and change.
research Scarless Wound Healing: Transitioning from Fetal Research to Regenerative Healing
Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.
research Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer
The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
research Edar Signaling in the Control of Hair Follicle Development
Edar signaling is crucial for proper hair follicle development and function.
research Neuroendocrine Perspectives in Alopecia Areata: Does Stress Play a Role?
Stress might contribute to hair loss in alopecia areata.
research The Itchy Scalp: Scratching for an Explanation
Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.
research Ethnodermatological Use of Medicinal Plants in India: From Ayurvedic Formulations to Clinical Perspectives – A Review
Indian herbal medicine shows promise for treating skin diseases but needs more research to prove effectiveness.
research Progenitor Cell Dysfunctions Underlie Some Diabetic Complications
Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.
research Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation
Desmoglein 4 is controlled by specific proteins that affect hair growth.
research Miz1 Is Required for Hair Follicle Structure and Hair Morphogenesis
Miz1 is essential for proper hair structure and growth.
research A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells
The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
research CXXC5: A Novel Regulator and Coordinator of TGF-β, BMP, and Wnt Signaling
CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.
research After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration
After skin is damaged, noncoding dsRNA helps prostaglandins and Wnts work together to repair tissue and promote hair growth.
research PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology
PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.
research Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis
Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.
research The Genetic Architecture of Alopecia Areata
Genetic discoveries are leading to new treatments for alopecia areata.
research Hair Growth Potential of Salvia Plebeia Extract and Its Associated Mechanisms
Salvia plebeia extract can stimulate hair growth.
research Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)–Deficient Canines
Mutations in NIPAL4 cause skin issues by disrupting lipid layers, but some improvement is seen with topical treatment.
research Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration
Zebrafish need MYC and FGF to regenerate inner ear hair cells.
research Class III Peroxidases PRX01, PRX44, and PRX73 Control Root Hair Growth in Arabidopsis Thaliana
PRX01, PRX44, and PRX73 are essential for root hair growth in Arabidopsis thaliana.
research The Role of Nrf2 in Hearing Loss
Activating Nrf2 can help protect against hearing loss.
research Integrated miRNA-mRNA Analysis Reveals Regulatory Pathways Underlying the Curly Fleece Trait in Chinese Tan Sheep
Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.