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Progesterone and its byproducts control a specific receptor in the brain independently of progesterone receptors, affecting conditions related to the menstrual cycle.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

New mouse models of Pemphigus show severe symptoms and need better treatments.

The research found that a specific skin cell type not only triggers hair growth but also controls hair color, and that aging can lead to hair loss and color changes.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Blocking Rab27a slows hair growth, while blocking Rab27b encourages it.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Lack of Cisd2 disrupts calcium balance in cells, leading to poorly functioning neutrophils.

Blood vessels and specific genes help turn cartilage into bone when bones heal.

Mutant mice help researchers understand hair growth and related genetic factors.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Neurosteroids show promise for treating epilepsy and more research is needed.

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Using skin stem cells and certain molecules might lead to scar-free skin healing.

LEF1 is essential for the development of airway glands and is regulated by the Wnt/ß-catenin pathway.

Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.

Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.

Not having enough or having too much of the protein Grainyhead-like 3 leads to various developmental problems.

Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.

Older mice healed wounds better but lost more weight and might have weaker immune systems afterward.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.