113 citations
,
April 1999 in “The Journal of Clinical Endocrinology and Metabolism” This study found that all four treatments—flutamide, finasteride, ketoconazole, and EE-CPA—significantly reduced hirsutism, but EE-CPA and flutamide appeared most effective, with varying effects on androgen levels and side-effect profiles.
97 citations
,
October 2019 in “Journal of Translational Medicine” This review discusses the use of very low-calorie ketogenic diets for obesity management and provides recommendations for nutrition experts, but reports no new clinical results.
92 citations
,
January 1998 in “Dermatology” This study found that 2% ketoconazole shampoo improved hair density and anagen follicle proportion in androgenic alopecia similarly to minoxidil treatment, suggesting a potential role for Malassezia in inflammation.
46 citations
,
August 1990 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, ketoconazole treatment improved acne in all women and reduced hirsutism in some, but it caused several side effects and requires careful monitoring.
43 citations
,
October 2002 in “International Journal of Cosmetic Science” This study found that 1% ketoconazole and 1% piroctone olamine shampoos increased hair shaft thickness and reduced hair shedding in men with telogen effluvium and androgenic alopecia associated with dandruff.
41 citations
,
November 1987 in “British Journal of Dermatology” This article reports on the use of ketoconazole for treating cutaneous leishmaniasis, but includes no new clinical trial findings.
39 citations
,
January 2019 in “Journal of Dermatological Treatment” This review found topical ketoconazole to be highly effective against Malassezia-related skin conditions, though other treatments may outperform it for Tinea and Candida infections.
36 citations
,
May 2004 in “The journal of small animal practice/Journal of small animal practice” In this study, a combined therapy of Cyclosporine A and ketoconazole resolved anal furunculosis in dogs within 10 weeks, but recurrences were noted in about 37% of cases.
28 citations
,
December 2003 in “Medical Hypotheses” This paper suggests that ketoconazole 2% shampoo may enhance finasteride's effectiveness in treating androgenetic alopecia by more completely inhibiting the dihydrotestosterone pathway.
24 citations
,
April 2005 in “The Journal of Dermatology” This study found that 2% ketoconazole solution stimulated hair growth significantly in a mouse model, suggesting potential benefits for male pattern hair loss.
23 citations
,
April 1999 in “The Journal of Clinical Endocrinology and Metabolism” This study found that flutamide, finasteride, ketoconazole, and EE-CPA all significantly reduced hirsutism scores, hair diameter, and hair growth rate in women with hirsutism over 12 months.
20 citations
,
January 1990 in “Journal of dermatological treatment” This study found that both ketoconazole 2% shampoo and selenium sulphide are effective for dandruff treatment, but ketoconazole also reduces hair growth.
16 citations
,
September 1990 in “Fertility and sterility” This study reported that ketoconazole may effectively normalize menstruation and reduce testosterone and hair growth in women with ovarian hyperandrogenism, though its safety needs further evaluation.
14 citations
,
May 2022 in “International Journal of Molecular Sciences” This study found that platelet-rich plasma therapy reduced inflammation and improved bladder function in a rat model of ketamine-induced ulcerative cystitis.
14 citations
,
February 2011 in “Drug Metabolism and Disposition” This study examined the pharmacokinetics of finasteride in pigs and found that ketoconazole coadministration affected its distribution across various plasma compartments, bile, and urine.
12 citations
,
March 2014 in “ISRN Pharmacology (Print)” This study demonstrated that Ketoconazole, Minoxidil, and Minoxidil with Tretinoin all significantly stimulated hair growth in mice, with Minoxidil alone showing the most effectiveness.
11 citations
,
December 2019 in “Dermatologic Therapy” This systematic review suggests that topical ketoconazole may improve hair regrowth and thickness in both animal and human studies for androgenetic alopecia, but further randomized controlled trials are needed.
10 citations
,
January 2014 in “Journal of Pharmaceutical Sciences” This study found that ketorolac tert-butyl ester enhances skin permeation and follicular absorption compared to ketorolac, highlighting the role of lipophilicity and solubility in prodrug design.
10 citations
,
September 2013 in “Nutrition” In this animal study, the ketogenic diet was associated with more severe biotin deficiency in biotin-deficient mice, suggesting that biotin supplementation is important when following this diet.
9 citations
,
August 2024 in “Cureus” This study reviewed existing knowledge and research, observing that ketoconazole shampoo is a safe and effective treatment for scalp seborrheic dermatitis, significantly improving irritation and scaling while maintaining low relapse rates and minimal side effects.
9 citations
,
November 1978 in “Diabetes Care” This study suggests that behavior modification, semistarvation ketogenic regimens, and surgical therapy could be experimental approaches for different degrees of obesity, with their efficacy varying by the degree of weight excess.
8 citations
,
November 2022 in “Cureus” In this study, patients with mild to moderate scalp seborrheic dermatitis experienced greater improvements in severity scores and quality of life with Lulican™ shampoo compared to Ketoconazole over four weeks, with similar safety profiles but better tolerability and cosmetic acceptability for LulicanTM.
8 citations
,
July 1983 in “Veterinary Quarterly” This study found that treating dermatomycosis in cats and dogs with ketoconazole for 20 days resulted in new hair growth and a high rate of clinical cure, with minimal side effects.
7 citations
,
December 2019 in “Pharmaceutics” This study found that co-administration of ketoconazole significantly altered the pharmacokinetics of dutasteride in rats, suggesting an interaction potential between dutasteride and azole antifungal drugs.
4 citations
,
March 2024 in “Food & Nutrition Research” This study found that a ketogenic diet was linked to lower weight loss outcomes in obese or overweight women with PCOS.
3 citations
,
February 2018 in “Australian Veterinary Journal” This article explores the possibility that veterinarians may test positive for ketamine due to occupational exposure, but it reports no specific new findings.
2 citations
,
November 2024 in “Acta Dermato Venereologica” In this case report, researchers describe an adult patient with CHILD syndrome whose skin lesions were successfully managed with topical ketoconazole, marking the first known instance of using this treatment without recurrence during follow-up.
2 citations
,
May 2021 in “Research Square (Research Square)” This study found that ketoconazole-loaded solid lipid nanoparticles significantly improved skin permeation and retention compared to a drug suspension and marketed product, demonstrating enhanced delivery into deeper skin layers.
2 citations
,
December 2019 in “Biomedical dermatology” In this study, researchers found that topical ketoconazole showed delayed hair growth compared to minoxidil in female pattern hair loss but had fewer side effects, though patient satisfaction was similar for both treatments.
1 citations
,
October 2024 in “Dermatology Practical & Conceptual” In this double-blind randomized controlled trial, both rosemary extract lotion and 2% ketoconazole lotion were effective for treating scalp seborrheic dermatitis, but rosemary lotion reduced itching more significantly, while ketoconazole was more effective in reducing dandruff.