Therapeutic Effect of Platelet-Rich Plasma on Bladder Overactivity in Ketamine-Induced Ulcerative Cystitis in Rats

May 2022 in “ International Journal of Molecular Sciences ”

Kuang‐Shun Chueh, Kuan‐Hua Huang, Jian‐He Lu, Tai-Jui Juan, Shu‐Mien Chuang, Rong‐Jyh Lin, Yi‐Chen Lee, Cheng‐Yu Long, Mei-Chen Shen, Ting-Wei Sun, Yung‐Shun Juan

platelet-rich plasma ketamine-induced ulcerative cystitis urothelial regeneration angiogenesis neurogenesis oxidative stress fibrosis PRP

TLDR Platelet-rich plasma improves bladder function and reduces overactivity in ketamine-induced bladder issues.

The study investigated the effects of platelet-rich plasma (PRP) on bladder dysfunction in a rat model of ketamine-induced ulcerative cystitis (KIC). It involved 36 female Sprague Dawley rats divided into four groups. PRP treatment significantly improved bladder function by reducing inflammation, fibrosis, and oxidative stress, while promoting urothelial regeneration, angiogenesis, and neurogenesis. The findings suggested that PRP could be a potential non-drug therapy for KIC, offering tissue repair and remodeling benefits. However, the study noted limitations due to its preclinical nature, indicating the need for further clinical studies to assess PRP's safety and efficacy in humans.

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Therapeutic Effect of Platelet-Rich Plasma on Bladder Overactivity in Ketamine-Induced Ulcerative Cystitis in Rats

Research cited in this study

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