research Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications
Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.
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780-810 / 1000+ results research Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis
Overexpressing follistatin in mice delays wound healing and reduces scar size.
research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis
The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.
research Regulation of Involucrin Gene Expression
Involucrin gene expression is controlled by specific proteins and signaling pathways.
research Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism
Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.
research Human Hair Follicle Organ Culture: Theory, Application, and Perspectives
Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.
research Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control
Stress can stop hair growth in mice, and treatments can reverse this effect.
research The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors
Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.
research Extraskeletal Actions of Vitamin D
Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.
research Androgen Actions on the Human Hair Follicle: Perspectives
Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.
research Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately
Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
research The Histopathologic Spectrum of Psoriasis
Psoriasis skin changes are complex and might need several biopsies for a clear diagnosis.
research Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli
Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.
research Epithelial Growth Control by Neurotrophins: Leads and Lessons from the Hair Follicle
Neurotrophins are important for hair growth and could help treat hair loss.
research Dissecting the Impact of Chemotherapy on the Human Hair Follicle
Chemotherapy damages hair follicles, causing hair loss and other cellular changes.
research Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone
Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.
research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression
The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.
research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis
Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.
research Actinic Keratosis: A Clinical and Epidemiological Review
Actinic keratosis can lead to skin cancer, is more common in fair-skinned people, and can be reduced with sunscreen and treated effectively.
research The Hair Growth Promoting Effect of Asiasari Radix Extract and Its Molecular Regulation
Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.
research FOXO1, TGF-β Regulation and Wound Healing
FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.
research Epidemiology of Skin Cancer in the Mature Patient
Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.
research Learning From Nudity: Lessons From The Nude Phenotype
The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
research Human αβ and γδ T Cells in Skin Immunity and Disease
Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.
research Inherited Ichthyoses: Generalized Mendelian Disorders of Cornification
Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.
research Clinical Findings, Cutaneous Pathology, and Response to Therapy in 21 Patients With Keratosis Pilaris Atrophicans
The study found that Keratosis Pilaris Atrophicans is a genetic skin condition that starts in childhood, involves inflammation and scarring, and current treatments are only somewhat effective.
research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes
TRPV3 in skin cells causes inflammation and cell death.
research N-Terminal Functional Domain of Gasdermin A3 Regulates Mitochondrial Homeostasis via Mitochondrial Targeting
Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
research Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways
There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation
HOXC13 is essential for hair and nail development by regulating Foxn1.