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    Glossary Keratin 2

    protein providing structural strength to skin, hair, and nails

    Keratin 2 (KRT2) is a type of protein found in the outer layer of the skin, hair, and nails. It plays a crucial role in providing structural strength and resilience to these tissues, helping to protect them from damage and wear. Mutations in the KRT2 gene can lead to skin disorders such as ichthyosis bullosa of Siemens, which is characterized by blistering and scaling of the skin.

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    1. Autosomal Recessive Hypotrichosis with Woolly Hair Caused by a Mutation in the Keratin 25 Gene Expressed in Hair Follicles Journal of Investigative Dermatology · 2016 · 50 citations
    2. Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development British Journal of Dermatology · 1999 · 19 citations
    3. The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family PloS one · 2016 · 14 citations
    4. Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert. 2004 · 62 citations
    5. Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2 PloS one · 2015 · 22 citations
    6. The Mean Staple Length of Wool Fibre Is Associated with Variation in the Ovine Keratin-Associated Protein 21-2 Gene Genes · 2020 · 4 citations
    7. Identification of the Keratin-Associated Protein 22-2 Gene in the Capra hircus and Association of Its Variation with Cashmere Traits Animals · 2023 · 1 citations
    8. Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2 British Journal of Dermatology · 1998 · 175 citations
    9. Chapter 2 The Human Keratin Genes and Their Differential Expression 1987 · 126 citations
    10. Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-associated Protein (KAP) Genes on Chromosome 21q22.1 2002 · 100 citations
    11. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3 Genomics · 2004 · 34 citations
    12. Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene on Fibre Traits in Inner Mongolia Cashmere Goats Asian-Australasian Journal of Animal Sciences · 2007 · 20 citations
    13. ANTI‐HAIR KERATIN MONOCLONAL ANTIBODY (HKN‐2) The Journal of Dermatology · 1985 · 13 citations
    14. A Mutational Hotspot in the 2B Domain of Human Hair Basic Keratin 6 (hHb6) in Monilethrix Patients Journal of Investigative Dermatology · 1998 · 34 citations
    15. A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11 Genomics · 1989 · 49 citations
    16. Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits Genes · 2017 · 42 citations
    17. Chemical modification of keratin fibers using 2‐iminothiorane hydrochloride Journal of applied polymer science · 2003 · 16 citations
    18. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    19. Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin and the phorbol ester 12-<i>O</i>-tetradecanoylphorbol-13-acetate Carcinogenesis · 1987 · 12 citations
    20. Peer Review #2 of "Potential use of human hair shaft keratin peptide signatures to distinguish gender and ethnicity (v0.1)" 2020
    21. Peer Review #2 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)" 2013
    22. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits Animals · 2019 · 7 citations
    23. 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression 2020
    24. Peer Review #1 of "Potential use of human hair shaft keratin peptide signatures to distinguish gender and ethnicity (v0.2)" 2020
    25. Characterization of the Human Hair Keratin–Associated Protein 2 (KRTAP2) Gene Family Journal of Investigative Dermatology · 2012 · 52 citations
    26. Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits Genes · 2017 · 29 citations
    27. The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain Differentiation · 2004 · 70 citations
    28. Immunological characteristics and histological distribution of human hair fibrous proteins studied with anti-hair keratin monoclonal antibodies HKN-2, HKN-4, and HKN-6. Journal of Histochemistry & Cytochemistry · 1986 · 52 citations
    29. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    30. Ovine KRTAP36-2: A New Keratin-Associated Protein Gene Related to Variation in Wool Yield Genes · 2023