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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

Certain drugs that block specific enzymes can help treat prostate diseases.

STAT5 activation is crucial for starting the hair growth phase.

Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Minoxidil can stop the growth of ovarian cancer cells without harming the heart.

Scientists successfully grew new hair follicles in regenerated mouse skin using mouse and human cells.

The engineered skin substitute helped grow skin with hair on mice.

The document concludes that more research is needed to reduce frequent hospital visits, addiction medicine education improves with specific training, early breast cancer surgery findings are emerging, nipple smears are not very accurate, surgery for older melanoma patients doesn't extend life, a genetic condition in infants can often be treated with one drug, doctors are inconsistent with blood clot medication, a certain gene may protect against cell damage, muscle gene overexpression affects many other genes, and some mitochondrial genes are less active in mice with tumors.

Different types of inactive melanocyte stem cells exist with unique characteristics and potential to develop into other cells.

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Good nutrition is crucial for health and preventing disease, and supplements can help prevent nutrient deficiencies.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

Epidermolytic ichthyosis can be inherited in a semidominant way with mild symptoms in carriers.

Loss of a specific protein in skin cells causes symptoms similar to psoriasis.

Deleting MED1 in skin cells causes hair loss and skin changes.

A two-step method was created in 2015 to make more cells that help with hair growth, but they need to be combined with other cells for 4 days to actually form new hair.

Researchers found a way to grow cashmere goat hair cells in a lab and discovered that certain conditions improve these cells' growth and characteristics.

Keeping β-catenin levels high in mammary cells disrupts their development and branching.

The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.

Experts met to improve care for ichthyosis patients in Spain.

Different types of resting melanocyte stem cells have unique characteristics and vary in their potential to become other cells.

The extracellular matrix affects where tumors can start in the body.

KRT80 may worsen cancer by increasing growth and spread, but its full effects on treatment and outcomes need more research.

Wnt signaling is crucial for skin development and hair growth.