October 2021 in “Journal of Investigative Dermatology” The study concludes that as skin matures from infancy to childhood, there are major changes in cell differentiation, stemness, and growth, leading to a stronger skin barrier in older children.
April 2018 in “Journal of Investigative Dermatology” Kaempferol helps skin stem cells grow and may improve skin thickness due to its 3-OH group.
April 2018 in “Journal of Investigative Dermatology” The human skin's outer layer has more variety in cell types and development paths than previously thought.
September 2016 in “Journal of dermatological science” Epidermal stem cells use integrin β1 and α6 as markers and CD271+ cells help maintain skin health and heal wounds.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” The early genes of a specific virus can cause abnormal skin cell growth and hair follicle changes.
11 citations,
June 2012 in “Acta histochemica” Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.
8 citations,
January 2013 in “BioMed Research International” Age, gender, and hair loss affect scalp characteristics differently in young Caucasian adults.
Toxins can disrupt skin stem cell balance, causing skin overgrowth or ulceration.
69 citations,
December 2015 in “Journal of Controlled Release” Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.
34 citations,
October 1975 in “Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis” 14 citations,
July 2016 in “Anatomical Science International” The study suggests that the arrector pili muscle is important for hair health and its damage might contribute to hair loss.
23 citations,
July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.
351 citations,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
253 citations,
April 2008 in “Current opinion in cell biology” Notch signalling helps skin cells differentiate and prevents tumors.
182 citations,
May 2003 in “Development” Myc activation reduces skin stem cells by affecting cell adhesion.
174 citations,
November 2016 in “Cell stem cell” Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.
170 citations,
November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.
153 citations,
October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
153 citations,
April 1998 in “Current Biology” The risk of skin tumors becoming malignant depends on the specific skin cell type affected.
143 citations,
May 2017 in “Nature cell biology” Wounded skin cells can revert to stem cells and help heal.
143 citations,
September 2008 in “Experimental gerontology” Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
137 citations,
April 2015 in “Nature Reviews Molecular Cell Biology” Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.
133 citations,
September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
126 citations,
April 2006 in “International Journal of Dermatology” The conclusion is that FFA and LPP have similar scalp biopsy features, making them hard to distinguish histologically, and FFA may be a specific kind of scarring hair loss.
107 citations,
June 1997 in “PubMed” EGFR is essential for normal hair development and follicle differentiation.
99 citations,
January 2014 in “Nature communications” Scientists created stem cells that can grow hair and skin.
88 citations,
December 2012 in “Journal of The European Academy of Dermatology and Venereology” Injecting CD34+ cell-containing platelet-rich plasma into the scalp can improve hair count and thickness in people with pattern hair loss.
84 citations,
December 2008 in “Developmental biology” Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.
82 citations,
March 2012 in “Development” Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.
74 citations,
June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics” Minoxidil foam enters hair follicles and skin for hair growth.