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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.

The document concludes that early recognition and treatment of primary cicatricial alopecia is crucial to prevent permanent hair loss.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

*Acorus calamus* has many medicinal benefits but needs more safety research.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

ALA-PDT is effective and safe for chronic X-ray dermatitis, providing complete or partial remission.

Somatostatin may help protect hair follicles from immune attacks.

Mathematical modeling can improve regenerative medicine by predicting biological processes and optimizing therapy development.

Mutations in the HEPHL1 gene cause abnormal hair and cognitive issues.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

Certain zinc transporters are essential for healthy skin and managing zinc in the body could help treat skin problems.

Using longer PEG chains helps nanoparticles penetrate hair follicles better, improving drug delivery for conditions like alopecia.

Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.

Oncogenic K-ras causes rapid cancerous changes in the mouth's lining.