Search

for
Search:

GlossaryInterleukin-7

protein crucial for T cell development and hair follicle maintenance

Interleukin-7 (IL-7) is a protein that plays a crucial role in the immune system by promoting the development and survival of T cells, which are essential for the body's defense against infections. It is also involved in the maintenance of hair follicles, and disruptions in IL-7 signaling can be linked to conditions like alopecia, where hair loss occurs due to immune system imbalances.

Related Terms

Sort by

Research

30 / 1000+ results

research Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

245 citations , October 2015 in “Nature medicine”

Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

research COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine

58 citations , February 2021 in “Mayo Clinic Proceedings”

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

research 1349 Stimulation of hair follicle stem cell proliferation through an IL-1α dependent activation of γδT-cells

May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain immune cells, when activated by specific signals, can encourage hair growth.

research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

140 citations , May 2013 in “The journal of immunology/The Journal of immunology”

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

research An overview of JAK/STAT pathways and JAK inhibition in alopecia areata

40 citations , August 2022 in “Frontiers in immunology”

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

research Emerging Therapies for Acne Vulgaris

22 citations , March 2018 in “American Journal of Clinical Dermatology”

New acne treatments show promise as alternatives to traditional therapies.

research Cutaneous wound healing: canine allogeneic ASC therapy

20 citations , June 2020 in “Stem Cell Research & Therapy”

Using stem cells from fat tissue can significantly improve wound healing in dogs.

research Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors

6 citations , December 2022 in “Journal of autoimmunity”

JAK inhibitors like tofacitinib may effectively treat Alopecia Areata.

research The role of lymphocytes in the development and treatment of alopecia areata

60 citations , September 2015 in “Expert Review of Clinical Immunology”

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables

86 citations , December 2001 in “Experimental dermatology”

Mutant mice help researchers understand hair growth and related genetic factors.

research Human αβ and γδ T Cells in Skin Immunity and Disease

83 citations , June 2018 in “Frontiers in immunology”

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

research Apoptosis and cutaneous biology

60 citations , June 1997 in “Journal of The American Academy of Dermatology”

Apoptosis is crucial for healthy skin and treating skin diseases.

research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update

52 citations , January 2013 in “Journal of Dermatological Science”

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

research FOXN1 deficient nude severe combined immunodeficiency

32 citations , January 2017 in “Orphanet journal of rare diseases”

FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.

research NF-κB in biology and targeted therapy: new insights and translational implications

1 citations , March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

research Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases

28 citations , June 2021 in “Frontiers in immunology”

A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.

research RANKL Induces Organized Lymph Node Growth by Stromal Cell Proliferation

42 citations , February 2012 in “The journal of immunology/The Journal of immunology”

RANKL causes lymph nodes to grow by making certain cells multiply.

research Targeting integrin pathways: mechanisms and advances in therapy

54 citations , January 2023 in “Signal Transduction and Targeted Therapy”

New therapies are being developed that target integrin pathways to treat various diseases.

research Stem cells supporting other stem cells

34 citations , January 2013 in “Frontiers in genetics”

Stem cells can help other stem cells by producing supportive factors.

research Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 Pathway

10 citations , June 2016 in “PLOS ONE”

Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing

research Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing

8 citations , October 2021 in “Microbiology spectrum”

Researchers identified five new potential targets for leishmaniasis treatment, suggesting repurposing existing drugs could be effective.

research Upadacitinib for management of alopecia areata and rheumatoid arthritis: Letter to the editor

April 2024 in “JEADV clinical practice”

Upadacitinib significantly improved both rheumatoid arthritis and alopecia areata in a patient.

research Elevation of circulating DNAs of disease-associated cytokines in serum cell-free DNA from patients with alopecia areata

January 2024 in “Bioscience trends”

Higher levels of certain DNAs in blood may indicate hair follicle damage in alopecia areata patients.

research Platelet‐rich plasma and regenerative dentistry

87 citations , March 2020 in “Australian Dental Journal”

Platelet-rich plasma might help tissue regeneration in dentistry, but results vary and more research is needed.

research Dermatologic Changes Associated With Interleukin 2 Administration

123 citations , September 1987 in “JAMA”

IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.

research Interrelation of immunity and tissue repair or regeneration

252 citations , July 2009 in “Seminars in Cell & Developmental Biology”

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Platelet‐rich plasma for androgenic alopecia: A randomized, placebo‐controlled, double‐blind study and combined mice model experiment

research Platelet‐rich plasma for androgenic alopecia: A randomized, placebo‐controlled, double‐blind study and combined mice model experiment

6 citations , March 2021 in “Journal of Cosmetic Dermatology”

PRP injections promote hair growth and increase hair density in androgenic alopecia.

research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations , August 2021 in “International journal of molecular sciences”

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds

research Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds

August 2018

Ajwain seed extract improved skin healing and hair growth in a mouse skin irritation model.

Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

7 citations , February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.