Skin-Infiltrating CD4+ Lymphoma Cells Depend on Hair Follicle-Derived IL-7

September 2016 in “ Journal of Dermatological Science ”

Takeya Adachi, Tetsuro Kobayashi, Eiji Sugihara, Keitaro Fukuda, Manabu Ohyama, Hideyuki Saya, Taketo Yamada, Masayuki Amagai, Keisuke Nagao

The study demonstrated that hair follicle-derived IL-7 was crucial for the maintenance of skin-infiltrating CD4+ lymphoma cells, which exhibited a resident memory T cell (TRM) phenotype. The research showed that hair follicles expressed IL-7 and IL-15, and the removal of IL-7 from hair follicles resulted in the loss of both CD4+ and CD8+ TRM in the epidermis. This highlighted the essential role of hair follicle-derived cytokines in TRM homeostasis within the skin, particularly in the context of cutaneous T cell lymphoma (CTCL) like mycosis fungoides.

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