Skin-Infiltrating CD4+ Lymphoma Cells Depend on Hair Follicle-Derived IL-7

September 2016 in “ Journal of Dermatological Science ”

Takeya Adachi, Tetsuro Kobayashi, Eiji Sugihara, Keitaro Fukuda, Manabu Ohyama, Hideyuki Saya, Taketo Yamada, Masayuki Amagai, Keisuke Nagao

hair follicle-derived IL-7 IL-7 IL-15 CD4+ lymphoma cells resident memory T cell TRM cutaneous T cell lymphoma CTCL mycosis fungoides epidermis cytokines hair follicle-derived interleukin-7 interleukin-7 interleukin-15 skin T cell lymphoma skin lymphoma

TLDR Hair follicles produce IL-7, which is essential for certain skin lymphoma cells to survive.

The study demonstrated that skin-infiltrating CD4+ lymphoma cells, which exhibit a tissue-resident memory T cell (TRM) phenotype, depended on hair follicle-derived IL-7 for their maintenance, even after neoplastic transformation. Researchers used a mouse model to show that conditional ablation of IL-7 from hair follicles led to a significant decrease in epidermotropic lymphoma cells, highlighting the critical role of hair follicle-derived cytokines in TRM homeostasis. The study also found that IL-7 was predominantly expressed in hair follicles and its expression was enhanced in cutaneous T cell lymphoma (CTCL) patients. These findings suggested that hair follicle/keratinocyte-derived cytokines could be potential therapeutic targets in CTCL.

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