This review highlights the potential of 3D bioprinting in developing functional, patient-specific artificial skin, addressing limitations of traditional skin grafts and advancing regenerative medicine applications.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that hemoglobin α expression in the epidermis is induced by oxidative stress and may function as an antioxidant, contributing to skin barrier function.
139 citations
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October 2005 in “Journal of Investigative Dermatology” This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.
122 citations
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April 2020 in “American Journal Of Pathology” This review discusses the multiple factors contributing to skin aging, including cellular changes and environmental influences, and highlights its recognition as a disease with significant implications beyond cosmetic concerns, without reporting new research results.
8 citations
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July 2025 in “Gels” This review discusses how functionalized hydrogels can modulate the microbiome to aid tissue regeneration and infection control, highlighting their potential to deliver therapeutic agents effectively and support beneficial immune responses.
2 citations
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July 2024 in “Frontiers in Veterinary Science” In this study, researchers using a multi-omics approach identified specific proteins involved in the hair follicle cycle of Inner Mongolia Cashmere Goats, finding that API5 affects apoptosis, while ribosomal proteins are highly expressed during the resting stage, providing insights into hair follicle growth and apoptosis.
2 citations
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January 2017 in “International journal of genetics and genomics” This study identified specific miRNAs associated with hair follicle development in chicken embryos, highlighting miR-1623's involvement in regulating WNT4 and contributing to hair follicle cell growth.
1 citations
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March 2024 in “International journal of molecular sciences” This review discusses how ionizing radiation causes skin damage by inducing cellular senescence in keratinocytes, which secrete inflammatory mediators, recruiting immune cells and exacerbating inflammation, impacting the skin barrier function and healing.
89 citations
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March 2001 in “Endocrine practice” This article provides diagnosis and treatment guidelines for hyperandrogenic disorders in women but reports no new clinical results; it offers a summary of accepted scientific information and suggestions for clinical practice.
50 citations
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September 2012 in “Developmental Biology” This study found that over-expressing Spry4 and Fgf10 modulates feather stem cells to alter feather morphologies in distinct ways, affecting barb branch formation and tissue structure.
12 citations
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March 2021 in “Regenerative Engineering and Translational Medicine” Exosomes from stem cells might help treat hair loss.
11 citations
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January 2015 in “PubMed” This study found that the 2,940 nm erbium: YAG laser may promote hair growth in C57BL/6 mice by speeding up transitions in the hair cycle and increasing hair follicle numbers.
10 citations
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November 2013 in “African Journal of Traditional Complementary and Alternative Medicines” In this study, herbal hair oils made from Cuscuta reflexa showed effectiveness in promoting hair growth, reducing dandruff, and minimizing hair fall when tested on human volunteers and rats.
2 citations
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May 2024 in “Australasian Journal of Dermatology” Early diagnosis, innovative treatments, and considering systemic conditions are crucial in dermatological care.
1 citations
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January 2023 in “Journal of Clinical Medicine” This study reported that Tomorrowlabs HIF strengthening factor [HSF] hair restoration technology significantly improved hair thickness, density, shine, and elasticity, while reducing hair loss by an average of 66.8% and enhancing hair growth by up to 32.5% in subjects with androgenic alopecia over nine months.
1 citations
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January 2017 in “Journal of Clinical and Diagnostic Research” This case series reported three instances where alopecia linked to sodium valproate was reversed after discontinuing the drug.
February 2024 in “BMC genomics” This study identified a gene variant in the TRPV3 gene that may explain the suri alpaca phenotype, characterized by longer and less crimped fleece, suggesting this variant's involvement in the development of these hair characteristics compared to the huacaya phenotype.
1 citations
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January 2017 in “Springer eBooks” The document explains how hair loss patterns in men and women, known as Androgenetic alopecia, are classified using the Hamilton-Norwood system for men and the Ludwig grade system for women.
December 2024 in “Research Journal of Topical and Cosmetic Sciences” This review examines the various causes of Alopecia, traditional synthetic treatments, and explores less harmful, natural alternatives with potential economic benefits, though it notes that these findings are based on reviewing existing studies rather than presenting new experimental data.
1010 citations
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August 2000 in “Cell” In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.
375 citations
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June 2013 in “Biochimica et biophysica acta. Molecular cell research” This review examines the process of cornification as a mode of programmed cell death and outlines how keratinocytes activate anti-cell death mechanisms to maintain epidermal homeostasis, but reports no new results.
117 citations
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April 2008 in “Developmental biology” This study identified that Eda-A1 unexpectedly induces placode inhibitors dkk4 and lrp4, indicating the importance of tightly regulated signaling for proper ectodermal organ development.
98 citations
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May 2016 in “Genes” This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.
85 citations
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January 1990 83 citations
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October 1998 in “The American Journal of Human Genetics” A specific gene mutation causes complete hair loss in an Irish Traveller family.
79 citations
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August 1998 in “The Journal of Cell Biology” In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.
63 citations
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February 2017 in “ACS biomaterials science & engineering” In this study, polydopamine emerged as a safe and effective alternative to traditional hair dyes like PPD for dyeing gray hair permanently, showing resistance to detergents and causing less toxicity and hair loss in mice.
54 citations
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January 2009 in “Development” This study concluded that Wnt/β-catenin signaling, through Shh and Bmp pathways, is crucial for determining hair follicle fate in embryonic epidermal development.
51 citations
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October 2024 in “Pharmaceutics” This review highlights the potential of permeation enhancers to improve the delivery of active ingredients across the skin, optimizing therapeutic outcomes despite challenges posed by individual variability and environmental factors, according to the authors' analysis of current understanding and applications in skincare and transdermal therapies.
46 citations
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August 2022 in “Animals” This study identified key genes and miRNAs involved in feather morphogenesis in Zhedong White geese, highlighting a negative correlation between FOXO3 and miR-144-y.