16 citations
,
March 2018 in “Seminars in Oncology” This article compares the immunology of cancer and the placenta and suggests that immunotherapy for pregnant cancer patients could be feasible with careful exploration, though no new clinical results are reported.
15 citations
,
April 2022 in “Immunology” This review discusses sex differences in immune responses to COVID-19 and highlights that males tend to experience more severe symptoms and higher mortality but reports no new clinical findings.
14 citations
,
January 2024 in “Skin Research and Technology” The study suggested certain immune cells might cause alopecia areata, but it was retracted.
14 citations
,
February 2023 in “Frontiers in immunology” This review discusses the range of cutaneous immune-related adverse events induced by immune checkpoint inhibitors and the proposed mechanisms underlying these skin reactions, but reports no new clinical results.
12 citations
,
December 2021 in “Frontiers in Medicine” This study observed that dermatological patients using certain immunosuppressants, like azathioprine and high-dose prednisolone, had a reduced humoral immune response to the Sinovac-CoronaVac COVID-19 vaccine compared to those without such treatments.
11 citations
,
July 2022 in “Frontiers in Immunology” This study identified four immune-related signaling molecules (LGR5, PTN, JAG1, and DKK1) associated with keloid, suggesting their potential role in its pathogenesis and as targets for new treatments.
11 citations
,
March 2020 in “Immunology” This study reports that immunologically inert and skewed immune cell populations in developing human skin may contribute to wound healing and structural changes during skin development.
10 citations
,
August 2020 in “Drug metabolism and drug interactions” This case series found that patients with the NUDT15 415C>T variant experienced severe azathioprine toxicity, suggesting genotype-based dosing could reduce adverse effects.
10 citations
,
January 2019 in “International Immunology” This review discusses the interactions between immune cells and the skin epithelium and their impact on maintaining barrier function, emphasizing the potential to enhance epithelial barrier function in inflammatory diseases.
10 citations
,
September 2014 in “European Journal of Dermatology” This case report describes a 29-year-old woman with longstanding alopecia areata who experienced improvement in her scalp hair loss after 7 years of topical treatment with squaric acid dibutylester.
9 citations
,
June 2023 in “Cells” This review summarizes recent findings on how the dysregulated PI3K/Akt/mTOR pathway contributes to immune-mediated inflammatory skin disorders and discusses the potential of natural products, synthetic compounds, and biologic agents in their treatment. However, it emphasizes the need for further research to develop effective therapies.
9 citations
,
August 2021 in “Experimental dermatology” This review examines the dysregulation of innate immune barriers in the early stages of hidradenitis suppurativa and calls for further research on the role of the hair follicle and immune responses, but reports no new results.
9 citations
,
August 2017 in “Photochemistry and Photobiology” This study found that isolated red light may serve as an alternative for photo-immunotherapy without additional photosensitizers, as it did not reduce keratinocyte differentiation markers or increase photo-oxidative damage, unlike treatment with IL-4 or UVA1/blue light.
7 citations
,
July 2025 in “International Journal of Dermatology” This meta-analysis found that patients with alopecia areata have significantly higher odds of also having immune-mediated diseases such as atopic dermatitis, autoimmune thyroiditis, inflammatory bowel disease, systemic lupus erythematosus, and vitiligo, suggesting a need for comprehensive screening and interdisciplinary management.
7 citations
,
October 2024 in “Frontiers in Immunology” In this study, researchers prepared a humanized CXCL12 antibody for alopecia areata treatment, finding it significantly delayed disease onset in mice and reduced immune cell activation, suggesting potential as an immune modulatory therapy.
7 citations
,
January 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that epithelial cells in the skin of live mice regulate the density and spatial organization of immune cells, which actively maintain their position despite constant cell turnover.
6 citations
,
October 2024 in “International Journal of Dermatology” In this study, researchers conducted single-cell RNA sequencing to reveal that proinflammatory fibroblasts and vascular endothelial cells play significant roles in the immune microenvironment of keloids, suggesting potential targets for new therapeutic approaches.
6 citations
,
September 2024 in “Journal of Clinical Medicine” This review explored the relationship between autoimmune thyroiditis and various autoimmune skin conditions, highlighting shared genetic markers and immunological mechanisms, such as disrupted immune tolerance and oxidative stress, which may contribute to the development of these disorders.
6 citations
,
June 2024 in “Biofabrication” This study used digital-light-processing bioprinting to create a 3D skin-on-a-chip model with a miniaturized vascular network to closely study immune cell interactions similar to real human skin, demonstrating the potential to analyze immune-T cell trafficking influenced by skin signals.
6 citations
,
March 2022 in “Actas Dermo-Sifiliográficas” This review discusses the characteristics and management of cutaneous immune-related adverse events from immune checkpoint inhibitors and notes their potential association with a favorable cancer treatment response.
6 citations
,
February 2022 in “Journal of immunology research” This study observed that exosomes from adipose-derived stem cells promoted hair growth by enhancing dermal papilla cell proliferation and activating signaling pathways, suggesting potential for treating immune-mediated alopecia.
6 citations
,
January 2019 in “Journal of dermatology” This letter to the editor discusses immune checkpoint inhibitor-related alopecia and insights into its pathophysiology using non-invasive diagnostic techniques, but reports no new clinical results.
6 citations
,
November 2018 in “American journal of transplantation” This study reported that using UVB preirradiation and anti-CD154 antibody treatment in a humanized mouse model prolonged hair follicle allograft survival and reduced immune cell infiltration without needing generalized immunosuppression.
6 citations
,
December 2013 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses recent advances in the understanding of alopecia areata, focusing on immunity and genetics, and presents potential targets for therapy without reporting new clinical results.
5 citations
,
October 2025 in “Expert Review of Clinical Immunology” This article reviews current and emerging treatments for alopecia areata, emphasizing the need for biomarker-driven patient stratification to optimize therapeutic strategies and reduce potential side effects; it reports no new clinical findings.
5 citations
,
February 2022 in “International Journal of Molecular Sciences” This review discusses the roles of distinct immune cell types in skin wound healing, highlighting findings from animal studies, but provides no new clinical results.
5 citations
,
January 2019 in “International Journal of STD & AIDS” This report discusses a rare case where immune reconstitution inflammatory syndrome in an HIV patient led to dermatologic, ophthalmologic, and neurologic complications due to secondary syphilis.
4 citations
,
June 2024 in “British Journal of Dermatology” This study found that treatment with EGFR inhibitors or mitogen-activated kinase inhibitors may compromise the immune privilege of human scalp hair follicles, suggesting new directions for managing drug-induced folliculitis.
4 citations
,
December 2020 in “Tissue Barriers” This review explores the immunological aspects of epidermal differentiation in loricrin knockout mice, offering insights into keratinization and potential intrinsic factors affecting immune function, but provides no new clinical findings.
4 citations
,
November 2016 in “Pediatric Clinics of North America” This article discusses the diagnostic and therapeutic approach for immune-mediated central nervous system diseases but reports no new clinical findings.