Immune-Mediated Disorders in Patients With Alopecia Areata: Systematic Review and Meta-Analysis

    July 2025 in “ International Journal of Dermatology ”
    Piotr K. Krajewski, Beata Jastrząb, Jacek C. Szepietowski … David Saceda‐Corralo
    Studysummary This meta-analysis found that patients with alopecia areata have significantly higher odds of also having immune-mediated diseases such as atopic dermatitis, autoimmune thyroiditis, inflammatory bowel disease, systemic lupus erythematosus, and vitiligo, suggesting a need for comprehensive screening and interdisciplinary management.
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    Research cited in this study 17

    1. A Case of Unexpected Successful Treatment of Alopecia Areata With Tralokinumab in a Patient With Atopic Dermatitis International Journal of Dermatology · 2025
    2. Pathogenesis of Paradoxical Alopecia Areata During Dupilumab Therapy: What Is Known and Unknown International Journal of Dermatology · 2025
    3. Genetic Links Between Atopy, Allergy, and Alopecia Areata: Insights From a Mendelian Randomization Study Allergy Asthma and Clinical Immunology · 2024
    4. Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences International journal of molecular sciences · 2024
    5. Prevalence of Autoimmune and Inflammatory Diseases and Mental Health Conditions Among an Alopecia Areata Cohort from a US Administrative Claims Database Journal of Dermatology · 2023
    6. Alopecia Areata and Risk of Atopic and Autoimmune Conditions: Population-Based Cohort Study Clinical and Experimental Dermatology · 2022
    7. Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata International journal of molecular sciences · 2022
    8. Evaluation of Several Immune and Inflammatory Indicators and Their Association with Alopecia Areata Journal of cosmetic dermatology · 2021
    9. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    10. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    11. Treatment of Alopecia Universalis with Topical Janus Kinase Inhibitors – A Double Blind, Placebo, and Active Controlled Pilot Study International Journal of Dermatology · 2018
    12. Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2018
    13. Association of Alopecia Areata with Atopic Dermatitis and Chronic Spontaneous Urticaria Allergy and asthma proceedings · 2018
    14. Comorbidities in Patients with Alopecia Areata Journal of the American Academy of Dermatology · 2017
    15. Understanding Autoimmunity of Vitiligo and Alopecia Areata Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics · 2016
    16. Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata The Journal of Clinical Endocrinology & Metabolism · 2015
    17. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007

    Related research 1

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023