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This study suggests that interleukin-15 plays a complex role in alopecia areata, potentially contributing to immune infiltration while also protecting against hair follicle immune privilege collapse and promoting hair growth.

This study found that a TYK2 inhibitor, BMS-986202, may restore immune privilege in hair follicles and promote hair regrowth in a humanized alopecia areata mouse model by inhibiting IL-12-mediated signaling.

This study found that higher serum IL-21 levels may serve as a promising diagnostic and prognostic marker for alopecia areata, strongly correlating with disease activity.

This study suggests that rather than inhibiting IL-15, selectively stimulating IL-15Ra-mediated signaling could be beneficial for managing alopecia areata and possibly other inflammatory hair loss conditions, as IL-15 promoted hair growth and maintained immune privilege in human hair follicles.

This study found that skin bacteria promote regeneration in wound-induced hair follicle neogenesis, suggesting a role for IL-1β signaling and challenging the belief that infection inhibits healing.

This study evaluated interleukin-26's antimicrobial activity in Hidradenitis Suppurativa and explored its potential role in chronic skin inflammation.

This study found that skin bacteria contribute to regeneration in wound healing and WIHN by promoting IL-1β signaling, challenging the view that sterility is always beneficial for healing small wounds.

This study found that in chronic alopecia areata, increased IL-17 expression and CD8+CD49a-Trm cell infiltration in hair follicles were associated with more severe histopathologic gradings, while Foxp3+mTreg infiltration decreased.

This study observed that mice treated with mrIL-36α showed differences in wound-induced hair neogenesis compared to those treated with PBS, indicating a potential role of mrIL-36α in hair growth after skin injury.

In this study, IL-1α and IL-7 were found to work together to activate epidermal γδ T-cells, which in turn promote hair follicle stem cell proliferation during mouse wound healing.

This study found that acne lesions and nonlesional skin in mild-to-moderate acne patients showed significant Th17-skewing and increased antimicrobials, suggesting systemic targets like IL-17/IL-23/IL-36 could be therapeutic.

This study found that IL-9 influences the behavior of human primary keratinocytes by promoting motility while reducing invasion potential through a novel mechanism independent of matrix-metalloproteinases.

In this study, researchers reported that IL-17C plays a key pro-inflammatory role in human skin diseases and may be a promising therapeutic target for inflammatory skin conditions.

This study found that IL-1α and IL-7 secreted from keratinocytes in a genetically engineered mouse model can stimulate the expansion of γδT-cells, aiding in the proliferation of epidermal stem cells for wound healing.

This study found that interleukin-1α and interleukin-7 secreted by keratinocytes enhance the proliferation of γδT-cells and epidermal stem cells, revealing mechanisms of stem cell activation during wound healing in mice.

This study suggests that ethyl acetate extract of Equisetum debile may be effective for functional food and nutraceutical use due to its strong 5α-reductase, IL-6 inhibition, and lipid peroxidation activities without cytotoxic effects.

This research suggests that hair follicle-derived cytokines IL-7 and IL-15 are crucial for maintaining resident memory T cells in the skin, which may be relevant for diseases like cutaneous T cell lymphoma.

In this study, three patients with extensive alopecia areata receiving ustekinumab treatment showed significant hair regrowth and decreased inflammation over 20 weeks, suggesting potential targeted treatment for this condition.

This study discovered that DNA damage independently induces IL-19 and IL-24 cytokines, which regulate senescence-associated secretory phenotype factors, suggesting potential pathways for treating cancer and age-related diseases.

This study found that combining metformin and clomifene citrate improved pregnancy outcomes and reduced miscarriage rates in women with PCOS and infertility undergoing intrauterine insemination.

This study found that adipose derived stem cells in areas of alopecia in patients with androgenetic alopecia showed different levels of various signaling proteins compared to other scalp and periumbilical regions.

ASLAN004 was safe and well-tolerated, supporting further development for treating certain diseases.

This study identifies six novel keratin genes from the chromosome 17q21.2 region, suggesting their association with hair follicles, while all 27 keratin genes in the domain have been characterized transcriptionally.

This study found that dihydrotestosterone (DHT) suppresses prostaglandin E2 and TGF-β induced IGF-I gene promoter activity in osteoblasts, suggesting complex interactions among bone growth regulators and potential complications from anabolic steroid use.

This study found that new hair follicles can form in scarred skin of injured mice, challenging the long-held belief that mammalian hair follicles cannot regenerate de novo.

In a proof-of-concept study at Xiangya Hospital, the researchers observed that combining tofacitinib with low-dose interleukin-2 helped maintain remission in refractory alopecia areata patients, with three out of four maintaining complete remission for 11–20 months post-treatment and no adverse events reported.

This study found that in a mouse model of Ross River virus-induced joint inflammation, targeting IL-17A and IL-17A/F heterodimers reduced disease severity.

The researchers reported that keratin 33A is a structural protein specific to goat cashmere hair, with increased winter expression in high-cashmere-producing breeds.

This study found that patients with psoriasis had a significantly higher prevalence of autoimmune diseases and other comorbidities compared to individuals without psoriasis.