Analysis of the Mechanism of IL-36α in Wound-Induced Hair Follicle Neogenesis
February 2019
TLDR IL-36α helps in growing new hair follicles when healing wounds, potentially aiding in hair growth.
The study, conducted 4 years ago, investigated the role of IL-36α in wound-induced hair follicle neogenesis (WIHN) in mice. The researchers created skin wounds on the mice and then injected either mrIL-36α or PBS into the healing wound from post-wound day 7 to 14. The healed skin was then analyzed at post-wound day 28. The researchers used various techniques such as RT-PCR, Flow Cytometry, and Western Blot to analyze the results. The study found that IL-36α plays a significant role in WIHN, suggesting it could be a potential target for promoting hair growth in wound healing. However, the exact mechanisms and potential applications in humans require further research.
